Gerry C. MacQuillan, Moataz S. Seyam, Peter Nightingale, James M. Neuberger, Nicholas Murphy – 25 August 2005 – Early identification of those patients with fulminant hepatic liver failure (FHF) who need a transplant greatly helps in their management. A number of prognostic criteria have recently been proposed, including arterial blood lactate and serum phosphate concentrations. To validate their use, we retrospectively studied 83 consecutive patients with FHF admitted to our intensive treatment unit between August 2000 and March 2003.

Shin Hwang, Sung‐Gyu Lee, Chul‐Soo Ahn, Kwang‐Min Park, Ki‐Hun Kim, Gi‐Won Song, Dong‐Sik Kim – 25 August 2005

25 August 2005

Georgios K. Glantzounis, Henryk J. Salacinski, Wenxuan Yang, Brian R. Davidson, Alexander M. Seifalian – 25 August 2005 – Oxidative stress is an important factor in many pathological conditions such as inflammation, cancer, ageing and organ response to ischemia‐reperfusion. Humans have developed a complex antioxidant system to eliminate or attenuate oxidative stress. Liver ischemia‐reperfusion injury occurs in a number of clinical settings, including liver surgery, transplantation, and hemorrhagic shock with subsequent fluid resuscitation, leading to significant morbidity and mortality.

Steven M. Kawut, Darren B. Taichman, Vivek N. Ahya, Sandra Kaplan, Christine L. Archer‐Chicko, Stephen E. Kimmel, Harold I. Palevsky – 25 August 2005 – It is not known whether patients with pulmonary arterial hypertension associated with portal hypertension (portopulmonary hypertension (PPHTN) have different disease characteristics from those of patients with other forms of pulmonary arterial hypertension.

Maurizio Pompili, Vincenzo Giorgio Mirante, Gianfranco Rondinara, Luigi Rainero Fassati, Fabio Piscaglia, Salvatore Agnes, Marcello Covino, Matteo Ravaioli, Stefano Fagiuoli, Giovanni Gasbarrini, Gian Ludovico Rapaccini – 25 August 2005 – Aims of this retrospective study were to analyze the efficacy and safety of percutaneous ethanol injection (PEI) and radiofrequency ablation (RFA) in cirrhotic patients with hepatocellular carcinoma (HCC) submitted to orthotopic liver transplantation (OLT).

Timothy M. Pawlik, Keith A. Delman, Jean‐Nicolas Vauthey, David M. Nagorney, Irene Oi‐Lin Ng, Iwao Ikai, Yoshio Yamaoka, Jacques Belghiti, Gregory Y. Lauwers, Ronnie T. Poon, Eddie K. Abdalla – 25 August 2005 – Vascular invasion and high histologic grade predict poor outcome after surgical resection or liver transplantation for hepatocellular carcinoma (HCC). Despite the known association between tumor size and vascular invasion, a proportion of patients with large tumors can be treated surgically with excellent outcomes.

Loukas Argyriou, Robert Pfitzmann, Lars‐Erik Wehner, Stefan Twelkemeyer, Peter Neuhaus, Karim Nayernia, Wolfgang Engel – 25 August 2005 – Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominantly inherited disorder characterized by cutaneous and mucosal telangiectasias, epistaxis and arteriovenous malformations in lung, liver, central nervous system, and gastrointestinal tract. Mutations in the genes for endoglin (ENG) and for activin A receptor type II‐like kinase 1 (ALK‐1) have been identified to be associated with HHT.

Michael J. Krowka – 25 August 2005

A. Obaid Shakil – 25 August 2005