Preoperative donor liver biopsy for adult living donor liver transplantation: Risks and benefits

Silvio Nadalin, Massimo Malagó, Camino Valentin‐Gamazo, Giuliano Testa, Hideo A. Baba, Chao Liu, Nils R. Frühauf, Randolph Schaffer, Guido Gerken, Andrea Frilling, Christoph E. Broelsch – 20 July 2005 – The role of liver biopsy (LB) in donor selection for adult living donor liver transplantation remains controversial, since the procedure is associated with additional potential risks for the donor. From April 1998 to August 2004, 730 potential living donors for 337 adult recipients underwent our multistep evaluation program. In 144 candidates, LB was performed.

Generalized, pruritic, ulcerating maculopapular rash necessitating cessation of sirolimus in a liver transplantation patient

Christopher Tracey, Carmel Hawley, Anthony Donald Griffin, Geoff Strutton, Stephen Lynch – 20 July 2005 – The use of sirolimus as an alternative to calcineurin antagonists has enabled the continuation of immunosuppression in patients with renal impairment with preservation of kidney function. Sirolimus is generally well tolerated, with the main causes of cessation of therapy related to its effect on blood lipid profile as well as leukopenia and thrombocytopenia.

Endovascular stent graft repair of abdominal aortic aneurysms after liver transplantation

Kristin L. Mekeel, W. Anthony Lee, Alan I. Reed, Alan W. Hemming – 20 July 2005 – It is estimated that 1.7% of orthotopic liver transplant recipients will develop abdominal aortic aneurysms (AAAs) after transplantation. It has been observed that these aneurysms expand faster in transplant recipients; therefore, aggressive surveillance for AAAs in transplant recipients is required. Endovascular aneurysm repair is rapidly becoming the standard of care, especially in patients with previous abdominal surgery and other significant comorbidities.

Safety and efficacy of a single bolus administration of recombinant factor VIIa in liver transplantation due to chronic liver disease

Raymond M. Planinsic, Jan van der Meer, Giuliano Testa, Luis Grande, Angel Candela, Robert J. Porte, R. Mark Ghobrial, Helena Isoniemi, Peter Billeskov Schelde, Elisabeth Erhardtsen, Goran Klintmalm, Sukru Emre – 20 July 2005 – Orthotopic liver transplantation (OLT) can be associated with excessive blood loss. As a result, there may be increased risk of adverse outcomes. Activated recombinant factor VII (rFVIIa) has demonstrated the ability to improve hemostasis in a variety of disorders; however, there has been a limited amount of research into its use in OLT.

Intrafamilial transmission of hepatitis C in Egypt

Mostafa K. Mohamed, Mohamed Abdel‐Hamid, Nabiel N. Mikhail, Fatma Abdel‐Aziz, Ahmed Medhat, Laurence S. Magder, Alan D. Fix, G. Thomas Strickland – 19 July 2005 – The incidence of hepatitis C (HCV) infection and associated risk factors were prospectively assessed in a cohort of 6,734 Egyptians from 2 rural villages who were negative for antibodies to HCV (anti‐HCV). Initial and follow‐up sera were tested for anti‐HCV by enzyme immunoassay (EIA), and possible incident cases were confirmed by using the microparticle enzyme immunoassay (MEIA) and tested for HCV RNA.

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