Whole fetal liver transplantation—A new approach to cell therapy

Ran Oren, Yigal Breitman, Eyal Gur, Alexandra Traister, Isabel Zvibel, Eli Brazovsky, David A. Shafritz, Zamir Halpern – 20 July 2005 – We recently developed a novel rat model for liver repopulation, heterografting of microliver slices, aimed at overcoming the limitations inherent in both whole liver and hepatocyte transplantations. The aim of the present study was to evaluate the potential of whole fetal liver transplantations to survive and differentiate within the adult liver, using the adult liver slice transplantation model.

Diarrhea in liver transplant recipients: Etiology and management

Philip M. Ginsburg, Paul J. Thuluvath – 20 July 2005 – Diarrhea is common after liver transplantation (LT). The true incidence of diarrhea in liver transplant recipients is unknown but possibly ranges from 10% to 43% based on a few published studies in other solid organ and bone marrow transplantation. Infectious etiologies, including cytomegalovirus (CMV), Clostridium difficile, and occasional atypical intestinal infections, are the most common causes. Diarrhea is also a frequent side effect of immunosuppressive medications.

Sequential and simultaneous revascularization in adult orthotopic piggyback liver transplantation

Wojciech G. Polak, Shungo Miyamoto, Balazs A. Nemes, Paul M.J.G. Peeters, Koert P. de Jong, Robert J. Porte, Maarten J.H. Slooff – 20 July 2005 – The aim of the study was to assess whether there is a difference in outcome after sequential or simultaneous revascularization during orthotopic liver transplantation (OLT) in terms of patient and graft survival, mortality, morbidity, and liver function. The study population consisted of 102 adult patients with primary full‐size piggyback OLT transplanted between January 1998 and December 2001.

Stress‐inducing factors in ICUs: What liver transplant recipients experience and what caregivers perceive

Gianni Biancofiore, Maria L. Bindi, Anna Maria Romanelli, Lucio Urbani, Franco Mosca, Franco Filipponi – 20 July 2005 – The aim of this study was to compare a number of potentially stress‐generating factors related to an intensive care unit (ICU) stay from the points of view of patients undergoing liver transplantation or elective major abdominal surgery and their caregivers in order to identify differences and similarities that may help to optimize patient care.

Biliary epithelial cell antibodies induce expression of toll‐like receptors 2 and 3: A mechanism for post–liver transplantation cholangitis?

Xupeng Ge, Mehmet Uzunel, Bo‐Göran Ericzon, Suchitra Sumitran‐Holgersson – 20 July 2005 – Studies to determine the role of preformed antibodies to biliary epithelial cells (BECs) in liver transplant rejections have been initiated. However, the clinical importance of these antibodies in the posttransplantation period still remains to be elucidated. Reactivity to BECs isolated from a normal healthy liver was investigated in sera of 56 patients before and after liver transplantation (LTX) using flow cytometry.

Transplantation of hepatitis B surface antigen–positive livers into hepatitis B virus–positive recipients and the role of hepatitis delta coinfection

Alessandro Franchello, Valeria Ghisetti, Alfredo Marzano, Renato Romagnoli, Mauro Salizzoni – 20 July 2005 – The scarcity of liver donors requires consideration of grafts from sources not previously used. Allografts from hepatitis B surface antigen (HBsAg)‐carriers without a significant liver disease have been proposed for liver transplant recipients with hepatitis B virus (HBV)‐related cirrhosis and hepatocellular carcinoma (HCC).

Intrafamilial transmission of hepatitis C in Egypt

Mostafa K. Mohamed, Mohamed Abdel‐Hamid, Nabiel N. Mikhail, Fatma Abdel‐Aziz, Ahmed Medhat, Laurence S. Magder, Alan D. Fix, G. Thomas Strickland – 19 July 2005 – The incidence of hepatitis C (HCV) infection and associated risk factors were prospectively assessed in a cohort of 6,734 Egyptians from 2 rural villages who were negative for antibodies to HCV (anti‐HCV). Initial and follow‐up sera were tested for anti‐HCV by enzyme immunoassay (EIA), and possible incident cases were confirmed by using the microparticle enzyme immunoassay (MEIA) and tested for HCV RNA.

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