Hepatitis C virus–specific CD8+ T cells restricted by donor HLA alleles following liver transplantation

George M. Lauer – 22 June 2005 – By necessity, human liver transplantation is performed across HLA barriers. As a result, intracellular infection of the allograft presents a unique immunologic challenge for the recipient's immune system. In this study, we describe the presence of HLA‐A2‐restricted, hepatitis C virus (HCV)‐specific CD8+ T cells in liver transplant recipients in whom the allograft is HLA‐A2 positive and the recipient is HLA‐A2 negative. These memory‐effector T cells are recipient derived and recognize HCV peptide uniquely in the context of HLA‐A2.

Liver transplantation for HCV‐related cirrhosis in a patient with gastric mucosa‐associated lymphoma (MALToma) pretreated with rituximab

Matthew R. Foxton, Lisa Knight, Alex S. Knisely, Ghulam J. Mufti, John O'Grady, Paolo Muiesan, Suzanne Norris – 22 June 2005 – End‐stage liver disease due to chronic hepatitis C virus (HCV) infection is now the most frequent indication for liver transplantation. HCV infection is associated with extrahepatic disease including cryoglobulinemia and lymphoma.

Hepatic B‐cell non‐Hodgkin's lymphoma of MALT type in the liver explant of a patient with chronic hepatitis C infection

Mauricio Orrego, Linsheng Guo, Craig Reeder, Giovanni De Petris, Vijayan Balan, David D. Douglas, Thomas Byrne, Edwyn Harrison, David Mulligan, Hector Rodriguez‐Luna, Adyr Moss, Kunam Reddy, Jorge Rakela, Hugo E. Vargas – 22 June 2005 – B‐cell non‐Hodgkin's lymphoma (B‐NHL) is a well‐documented complication of hepatitis C virus (HCV) infection. Marginal zone (mucosa‐associated lymphoid tissue; MALT) lymphomas constitute a less common type of B‐NHL. In this article, we report a case of liver MALT in a cirrhotic patient, incidentally discovered after liver transplantation (LT).

Right hepatic lobe donation adversely affects donor life insurability up to one year after donation

Matthew H. Nissing, Paul H. Hayashi – 22 June 2005 – There are no data regarding hepatic lobe donation effects on donor life insurability. Two investigators called 10 agents of 10 different large life insurance companies. One investigator gave a fictitious profile: Caucasian man, 33 years old, nonsmoker, without medical problems (control profile [CP]). The other investigator used the same profile with a history of uncomplicated right lobe donation 12 months earlier (donor profile [DP]). Investigators asked for premium quotes on a $100,000 term life policy.

Changes in oxyhemoglobin dissociation curve in intrabdominal organs during pig experimental orthotopic liver transplantation

Georgia Kostopanagiotou, Kassiani Theodoraki, Ageliki Pandazi, Nikolaos Arkadopoulos, Konstantinos Kostopanagiotou, Vassilios Smyrniotis – 22 June 2005 – Liver transplantation has become a gold standard treatment for irreversible liver disease. Conventional measures of oxygenation are inadequate to understand the dynamics of regional oxygen metabolism during liver transplantation because they represent global markers of tissue dysoxia.

“All‐in‐one” imaging protocols for the evaluation of potential living liver donors: Comparison of magnetic resonance imaging and multidetector computed tomography

Tobias Schroeder, Massimo Malagó, Jörg F. Debatin, Mathias Goyen, Silvio Nadalin, Stefan G. Ruehm – 22 June 2005 – In order to compare the performance of “all‐in‐one” magnetic resonance imaging (MRI) and “all‐in‐one” multidetector computed tomography (MDCT) in the preharvest evaluation 25 potential living donors underwent both MRI and MDCT. MRI was performed on a high‐performance 1.5‐T scanner, computed tomography (CT) on a 4‐row multidetector‐scanner. Both scan protocols included angiography of the arterial and venous hepatic systems.

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