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Thomas D. Boyer – 16 June 2005
Ischemia/reperfusion accelerates the outgrowth of hepatic micrometastases in a highly standardized murine model
Jarmila D. W. van der Bilt, Onno Kranenburg, Maarten W. Nijkamp, Niels Smakman, Liesbeth M. Veenendaal, Elisabeth A. te Velde, Emile E. Voest, Paul J. van Diest, Inne H. M. Borel Rinkes – 16 June 2005 – Mortality in colorectal cancer is associated with the development of liver metastases. Surgical removal of these tumors is the only hope for cure, but recurrence is common. During liver surgery, ischemia/reperfusion (I/R) often occurs as a result of hemorrhage or vascular clamping.
Of mice and women: Toward a mouse model of autoimmune hepatitis
Michael A. Heneghan, Ian G. McFarlane – 16 June 2005
Activation and function of hepatocyte NF‐κB in postischemic liver injury
Alex B. Lentsch – 16 June 2005 – The inhibitor of NF‐κB (I‐κB) kinase (IKK) complex consists of 3 subunits, IKK1, IKK2, and NF‐κB essential modulator (NEMO), and is involved in the activation of NF‐κB by various stimuli. IKK2 or NEMO constitutive knockout mice die during embryogenesis as a result of massive hepatic apoptosis. Therefore, we examined the role of IKK2 in TNF‐induced apoptosis and ischemia/reperfusion (I/R) injury in the liver by using conditional knockout mice.
Reactivation of viral replication after replacement of tenofovir by adefovir
Florian van Bömmel, Thomas Berg – 16 June 2005
Male cell microchimerism in normal and diseased female livers from fetal life to adulthood
Catherine Guettier, Mylène Sebagh, Jérôme Buard, Danielle Feneux, Monique Ortin‐Serrano, Michele Gigou, Viviane Tricottet, Michel Reynès, Didier Samuel, Cyrille Féray – 16 June 2005 – Male microchimerism is frequent in the adult female liver and is attributed to fetal cells originating from previous male offspring. It has never been studied in pregnant women, female children, or fetuses. We examined its frequency and cellular nature in normal and diseased female livers from fetal life to adulthood.
Methodological issues and the measurement of fatigue in primary biliary cirrhosis
Dennis A. Revicki – 16 June 2005
Milk thistle and chronic liver disease
Jay H. Hoofnagle – 16 June 2005
Cytoplasmic retention of peroxide‐activated ERK provides survival in primary cultures of rat hepatocytes
Carola M. Rosseland, Lene Wierød, Morten P. Oksvold, Heidi Werner, Anne Carine Østvold, G. Hege Thoresen, Ragnhild E. Paulsen, Henrik S. Huitfeldt, Ellen Skarpen – 16 June 2005 – Reactive oxygen species (ROS) are implicated in tissue damage causing primary hepatic dysfunction following ischemia/reperfusion injury and during inflammatory liver diseases. A potential role of extracellular signal‐regulated kinase (ERK) as a mediator of survival signals during oxidative stress was investigated in primary cultures of hepatocytes exposed to ROS.
Outcome of hepatitis B e antigen–negative chronic hepatitis B on long‐term nucleos(t)ide analog therapy starting with lamivudine
George V. Papatheodoridis, Evangelini Dimou, Konstantinos Dimakopoulos, Spilios Manolakopoulos, Irene Rapti, George Kitis, Dimitrios Tzourmakliotis, Emanuel Manesis, Stephanos J. Hadziyannis – 16 June 2005 – We determined the clinical outcome of hepatitis e antigen (HBeAg)‐negative chronic hepatitis B patients treated with long‐term nucleos(t)ide analog therapy starting with lamivudine. We evaluated 201 such patients treated for 3.8 ± 1.4 years and 2 historical similar cohorts: 1 treated with interferon‐alfa (n = 209) and 1 untreated (n = 195).