22 June 2005

Mauricio Orrego, Linsheng Guo, Craig Reeder, Giovanni De Petris, Vijayan Balan, David D. Douglas, Thomas Byrne, Edwyn Harrison, David Mulligan, Hector Rodriguez‐Luna, Adyr Moss, Kunam Reddy, Jorge Rakela, Hugo E. Vargas – 22 June 2005 – B‐cell non‐Hodgkin's lymphoma (B‐NHL) is a well‐documented complication of hepatitis C virus (HCV) infection. Marginal zone (mucosa‐associated lymphoid tissue; MALT) lymphomas constitute a less common type of B‐NHL. In this article, we report a case of liver MALT in a cirrhotic patient, incidentally discovered after liver transplantation (LT).

Matthew R. Foxton, Lisa Knight, Alex S. Knisely, Ghulam J. Mufti, John O'Grady, Paolo Muiesan, Suzanne Norris – 22 June 2005 – End‐stage liver disease due to chronic hepatitis C virus (HCV) infection is now the most frequent indication for liver transplantation. HCV infection is associated with extrahepatic disease including cryoglobulinemia and lymphoma.

Pieter Evenepoel, Bert Bammens, Frederik Nevens, Alexander Wilmer, Yves Vanrenterghem – 22 June 2005

Elizabeth Anne Pomfret – 22 June 2005

George M. Lauer – 22 June 2005 – By necessity, human liver transplantation is performed across HLA barriers. As a result, intracellular infection of the allograft presents a unique immunologic challenge for the recipient's immune system. In this study, we describe the presence of HLA‐A2‐restricted, hepatitis C virus (HCV)‐specific CD8+ T cells in liver transplant recipients in whom the allograft is HLA‐A2 positive and the recipient is HLA‐A2 negative. These memory‐effector T cells are recipient derived and recognize HCV peptide uniquely in the context of HLA‐A2.

Sabine Stahl, Carina Ittrich, Philip Marx‐Stoelting, Christoph Köhle, Özge Altug‐Teber, Olaf Riess, Michael Bonin, Jürgen Jobst, Stephan Kaiser, Albrecht Buchmann, Michael Schwarz – 17 June 2005 – Experimentally induced liver tumors in mice harbor activating mutations in either Catnb (β‐catenin) or Ha‐ras, according to the carcinogenic treatment. We have now investigated by microarray analysis the gene expression profiles in tumors of the two genotypes.

Harald F. Teutsch – 17 June 2005 – The morphological homogeneity of the liver parenchyma has represented a major obstacle in finding an acceptable definition of the structural/functional units of the liver. Concepts such as the “lobule,” the “portal unit” and the “acinus” remain debatable. This study investigates the modular microarchitecture on the basis of the lobular concept. Using alkaline phosphatase activity as a histochemical marker, modules could be recognized clearly.

Christopher R. Longo, Virendra I. Patel, Gautam V. Shrikhande, Salvatore T. Scali, Eva Csizmadia, Soizic Daniel, David W. Sun, Shane T. Grey, Maria B. Arvelo, Christiane Ferran – 16 June 2005 – The liver has a remarkable regenerative capacity, allowing recovery following injury. Regeneration after injury is contingent on maintenance of healthy residual liver mass, otherwise fulminant hepatic failure (FHF) may arise. Understanding the protective mechanisms safeguarding hepatocytes and promoting their proliferation is critical for devising therapeutic strategies for FHF.

Teh‐Ia Huo, Jaw‐Ching Wu, Shou‐Dong Lee – 16 June 2005