Regino P. González‐Peralta, Deirdre A. Kelly, Barbara Haber, Jean Molleston, Karen F. Murray, Maureen M. Jonas, Mark Shelton, Giorgina Mieli‐Vergani, Yoav Lurie, Steven Martin, Thomas Lang, Andrew Baczkowski, Michael Geffner, Samir Gupta, Mark Laughlin, for the International Pediatric Hepatitis C Therapy Group – 25 October 2005 – Chronic hepatitis C virus (HCV) infection is usually asymptomatic in children, but significant liver disease may occur. We evaluated the efficacy, safety, and pharmacokinetics of interferon alfa‐2b and ribavirin in children with chronic HCV.

Meta W. Djojosubroto, Allison C. Chin, Ning Go, Sonja Schaetzlein, Michael P. Manns, Sergei Gryaznov, Calvin B. Harley, K. Lenhard Rudolph – 25 October 2005 – Most cancer cells have an immortal growth capacity as a consequence of telomerase reactivation. Inhibition of this enzyme leads to increased telomere dysfunction, which limits the proliferative capacity of tumor cells; thus, telomerase inhibition represents a potentially safe and universal target for cancer treatment.

David A. Rudnick – 25 October 2005

José E. Manautou, Dirk R. de Waart, Cindy Kunne, Noam Zelcer, Michael Goedken, Piet Borst, Ronald Oude Elferink – 25 October 2005 – MRP3 is an ABC transporter localized in the basolateral membrane of epithelial cells such as hepatocytes and enterocytes. In this study, the role of Mrp3 in drug disposition was investigated. Because Mrp3 preferentially transports glucuronide conjugates, we investigated the in vivo disposition of acetaminophen (APAP) and its metabolites. Mrp3+/+ and Mrp3−/− knockout mice received APAP (150 mg/kg), and bile was collected.

Sumita Verma, Allan Redeker – 25 October 2005

Robert H. Costa, Vladimir V. Kalinchenko, Yongjun Tan, I‐Ching Wang – 25 October 2005

Domenico Sansonno, Felicia Anna Tucci, Valli De Re, Gianfranco Lauletta, Michele Montrone, Massimo Libra, Franco Dammacco – 25 October 2005 – Infection with HCV can be associated with B‐cell non‐Hodgkin lymphoma. Polymerase chain reaction (PCR) amplification assays for Bcl‐2/IgH rearrangement were performed on nucleic acids extracted from portal tract inflammatory infiltrates, isolated with laser capture microdissection (LCM), from liver biopsy sections of 16 hepatitis C virus (HCV)‐infected patients with and without extrahepatic B cell–related disorders.

Andres T. Blei – 19 October 2005

Adrian M. Di Bisceglie – 19 October 2005

James Neuberger – 19 October 2005