Maureen M. Jonas – 28 November 2005

Egbert Sieders, Bouke G. Hepkema, Paul M.J.G. Peeters, Elisabeth M. TenVergert, Koert P. de Jong, Robert J. Porte, Charles M.A. Bijleveld, Aad P. van den Berg, Simon P.M. Lems, Annette S.H. Gouw, Maarten J.H. Slooff – 28 November 2005 – The aim of this study was to analyze the effect of human leukocyte antigen (HLA) class I and HLA‐DR mismatching, sharing cross‐reactive antigen groups (CREGs), and sharing HLA‐DR antigens on the outcome after pediatric liver transplantation. Outcome parameters were graft survival, acute rejection, and portal fibrosis.

Stefano Ginanni Corradini, Fausta Micheletta, Silvia Natoli, Massimo Iappelli, Emanuele Di Angelantonio, Rosanna De Marco, Walter Elisei, Maria Siciliano, Massimo Rossi, Pasquale Berloco, Adolfo Francesco Attili, Ulf Diczfalusy, Luigi Iuliano – 28 October 2005 – Oxidative stress is implicated in the pathogenesis of hepatic ischemia‐reperfusion injury, a major determinant of initial poor graft function (IPGF) after orthotopic liver transplantation (OLT).

Ian Gooding, Vicky Dondos, Khin Ma Gyi, Margaret Hodson, David Westaby – 28 October 2005 – Autopsy and imaging studies show that liver involvement is common in cystic fibrosis. However, complications of chronic liver disease including portal hypertension and variceal bleeding are infrequently encountered, and the degree to which variceal hemorrhage affects prognosis in cystic fibrosis is unclear. This uncertainty has lead to debate as to whether liver transplantation is indicated in these patients.

Combes Burton – 25 October 2005

Robert A. DeAngelis, Maciej M. Markiewski, Rebecca Taub, John D. Lambris – 25 October 2005 – Despite the growing incidence of obesity, knowledge of how this condition, as well as associated steatosis, affects liver regeneration remains scarce. Many previous studies have used models of steatohepatitis or obesity induced by genetic alterations. In contrast, our studies on liver regeneration have focused on the effects of obesity resulting solely from high amounts of fat in the diet.

Oliviero Riggio, Cesare Efrati, Carlo Catalano, Federica Pediconi, Oriano Mecarelli, Neri Accornero, Francesca Nicolao, Stefania Angeloni, Andrea Masini, Lorenzo Ridola, Adolfo F. Attili, Manuela Merli – 25 October 2005 – Large spontaneous portal‐systemic shunts have been occasionally described in patients with cirrhosis. This study was undertaken to assess the prevalence of portal‐systemic shunts in patients with cirrhosis with recurrent or persistent hepatic encephalopathy (HE) as compared with patients with cirrhosis without HE.

Hongqun Liu, Samuel S. Lee – 25 October 2005

Darren J. Schofield, Birke Bartosch, Yohko K. Shimizu, Tobias Allander, Harvey J. Alter, Suzanne U. Emerson, François‐Loïc Cosset, Robert H. Purcell – 25 October 2005 – Active and/or passive immunoprophylaxis against hepatitis C virus (HCV) remain unachieved goals. Monoclonal antibodies might provide one approach to protection. We derived human monoclonal antibodies from the bone marrow of a patient with a well‐controlled HCV infection of 22 years duration.

Daniel Benten, Vinay Kumaran, Brigid Joseph, Jörn Schattenberg, Yury Popov, Detlef Schuppan, Sanjeev Gupta – 25 October 2005 – We investigated whether transplanted hepatocytes interact with hepatic stellate cells, as cell–cell interactions could modulate their engraftment in the liver. We transplanted Fischer 344 rat hepatocytes into syngeneic dipeptidyl peptidase IV–deficient rats.