28 November 2005

Brendan M. McGuire, Herbert L. Bonkovsky, Robert L. Carithers, Raymond T. Chung, Leonard I. Goldstein, John R. Lake, Anna S. Lok, Carol J. Potter, Elizabeth Rand, Michael D. Voigt, Pamela R. Davis, Joseph R. Bloomer – 28 November 2005 – In erythropoietic protoporphyria (EPP), there is excessive production of protoporphyrin, primarily in the bone marrow, resulting in increased biliary excretion of this heme precursor. Some patients will develop progressive liver disease that may ultimately require liver transplantation.

Shintaro Yamazaki, Tadatoshi Takayama, Kazuto Inoue, Tokio Higaki, Masatoshi Makuuchi – 28 November 2005

Trevor N. Johnson, Geoffrey T. Tucker, M. Stuart Tanner, Amin Rostami‐Hodjegan – 28 November 2005 – A diversity of equations is available for the estimation of liver volume (LV), derived from studies in populations of ethnically homogeneous individuals and using a variety of methods of measurement. The aim of this study was to integrate all published pediatric data and to define a general equation for estimating LV from birth onward. Data were collated from 5,036 subjects (birth to 18 yr old).

Janis E. Blair, Shimon Kusne – 28 November 2005

Peter Boros, Gabriel Gondolesi, Jonathan S. Bromberg – 28 November 2005 – Intravenous immunoglobulin (IVIg) treatment was introduced as replacement therapy for patients with antibody deficiencies, but evidence suggests that a wide range of immune‐mediated conditions could benefit from IVIg. The immunoglobulins are precipitated from human plasma by fractionation methods. In conclusion, the differences in basic fractionation methods and the addition of various modifications for purification, stabilization, and virus inactivation result in products significantly different from each other.

Yusuke Yonemura, Akinobu Taketomi, Yuji Soejima, Tomoharu Yoshizumi, Hideaki Uchiyama, Tomonobu Gion, Noboru Harada, Hideki Ijichi, Kengo Yoshimitsu, Yoshihiko Maehara – 28 November 2005 – Reconstruction of middle hepatic vein (MHV) tributaries is controversial in right‐lobe living donor liver transplantation (LDLT). This study aimed to evaluate the appropriateness of reconstructing MHV tributaries by volumetry using 3‐dimensional computed tomography (3D‐CT).

Kenji Kihara, Shinichi Ueno, Masahiko Sakoda, Takashi Aikou – 28 November 2005 – Recent studies have shown that hyperbaric oxygen therapy (HBOT) reduces neutrophil endothelial adherence in venules and also blocks the progressive arteriolar vasoconstriction associated with ischemia‐reperfusion (I‐R) injury in the extremities and the brain. In order to elucidate the effects of HBOT after I‐R in digestive organs, particularly in the liver, we evaluated the following: 1) the relationship between timing of HBOT and tissue damage; and 2) HBOT's effects on neutrophil sequestration.

Martin Vogel, Esther Voigt, Nico Schäfer, Georg Goldmann, Nicolas Schwarz, Jörg C. Kalff, Tilman Sauerbruch, Martin Wolff, Jürgen Kurt Rockstroh, Ulrich Spengler – 28 November 2005 – The outcome and clinical features of 7 HIV‐positive patients who were liver transplanted at Bonn University in the era of highly active antiretroviral therapy (HAART) between 1997 and 2004, analyzed by retrospective chart review, are reported.

Claire Terry, Anil Dhawan, Ragai R. Mitry, Sharon C. Lehec, Robin D. Hughes – 28 November 2005 – Cryopreservation of human hepatocytes is important for the treatment of liver disease by hepatocyte transplantation and also for the use of hepatocytes as an in vitro model of the liver. One factor in the success of cryopreservation is the quality of cells before freezing.