Microcirculation of the aging liver: Is getting old like having cirrhosis?
Pierre‐Michel Huet, Jean‐Pierre Villeneuve – 29 November 2005
AASLD 2005 distinguished service award to Dr. Leonard B. Seeff
Jay H. Hoofnagle – 29 November 2005
Alcohol increases tumor necrosis factor α and decreases nuclear factor‐κb to activate hepatic apoptosis in genetically obese mice
Marie‐Anne Robin, Christine Demeilliers, Angéla Sutton, Valérie Paradis, Caroline Maisonneuve, Sylvie Dubois, Odile Poirel, Philippe Lettéron, Dominique Pessayre, Bernard Fromenty – 29 November 2005 – Both obesity and alcohol can cause oxidative stress, cytokine induction, and steatohepatitis. To determine the consequences of their combination, we compared the hepatic effects of moderate ethanol binges in lean and obese ob/ob mice. Mice received water or ethanol (2.5 g/kg) by gastric intubation daily for 4 days, and were killed 2 hours after the last administration.
Accelerated hepatitis C virus kinetics but similar survival rates in recipients of liver grafts from living versus deceased donors
Thomas D. Schiano, Julio A. Gutierrez, Jose L. Walewski, M. Isabel Fiel, Bonnie Cheng, Henry Bodenheimer, Swan N. Thung, Raymond T. Chung, Myron E. Schwartz, Carol Bodian, Andrea D. Branch – 29 November 2005 – This study tested the hypothesis that hepatitis C virus (HCV) RNA and core antigen levels rise more rapidly after liver transplantation (LT) in recipients of grafts from living donors (LD) versus deceased donors (DD). Eleven consecutive LD and 15 DD recipients were followed prospectively. Before LT, median HCV RNA levels were similar: 5.42 (LDLT) and 5.07 (DDLT) log10 IU/mL (P = NS).
HCV: Alive and kicking in living donor liver grafts?
Xavier Forns – 29 November 2005
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Gary A. Abrams, Ronald H. Clements, Audrey J. Lazenby, Sachin S. Kunde – 29 November 2005
AASLD 2005 distinguished achievement award to Dr. Jenny Heathcote
Samuel S. Lee – 29 November 2005
Spectrum of NAFLD and diagnostic implications of the proposed new normal range for serum ALT in obese women
Daniele Prati, Agostino Colli, Dario Conte, Massimo Colombo – 29 November 2005
OSTα‐OSTβ: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia
Nazzareno Ballatori, Whitney V. Christian, Jin Young Lee, Paul A. Dawson, Carol J. Soroka, James L. Boyer, Michael S. Madejczyk, Na Li – 29 November 2005 – The cellular and subcellular localization and mechanism of transport of the heteromeric organic solute transporter (OST) OSTα‐OSTβ was examined in human and rodent epithelia. The two subunits of the transporter were expressed together in human small intestine, kidney, and liver, tissues that also express the apical sodium‐dependent bile acid uptake transporter ASBT (SLC10A2).
A prospective study on downstaging of hepatocellular carcinoma prior to liver transplantation
Francis Y. Yao, Ryutaro Hirose, Jeanne M. LaBerge, Timothy J. Davern, Nathan M. Bass, Robert K. Kerlan, Raphael Merriman, Sandy Feng, Chris E. Freise, Nancy L. Ascher, John P. Roberts – 28 November 2005 – In patients with hepatocellular carcinoma (HCC) exceeding conventional (T2) criteria for orthotopic liver transplantation (OLT), the feasibility and outcome following loco‐regional therapy intended for tumor downstaging to meet T2 criteria for OLT are unknown.