Robert A. DeAngelis, Maciej M. Markiewski, Rebecca Taub, John D. Lambris – 25 October 2005 – Despite the growing incidence of obesity, knowledge of how this condition, as well as associated steatosis, affects liver regeneration remains scarce. Many previous studies have used models of steatohepatitis or obesity induced by genetic alterations. In contrast, our studies on liver regeneration have focused on the effects of obesity resulting solely from high amounts of fat in the diet.

Combes Burton – 25 October 2005

David J. Post, David D. Douglas, David C. Mulligan – 19 October 2005

Connie L. Davis – 19 October 2005 – Renal and hepatic function are often intertwined both through the existence of associated primary organ diseases and hemodynamic interrelationships. This connection occasionally results in the chronic failure of both organs, necessitating the need for combined kidney‐liver transplantation. Since 1990, over 1,790 patients in the United States have received such transplants with a patient survival somewhat less than that for patients receiving either organ alone.

Peter Ghali, Paul J. Marotta, Eric M. Yoshida, Vincent G. Bain, Denis Marleau, Kevork Peltekian, Peter Metrakos, Marc Deschênes – 19 October 2005 – Cholangiocarcinoma is a biliary tumor, which not infrequently complicates primary sclerosing cholangitis. It carries a poor prognosis and, with the exception of carefully selected individuals in research protocols, contraindicates orthotopic liver transplantation. There has been some suggestion that cholangiocarcinomas incidentally discovered at the time of transplantation carry a better prognosis.

Peter G. Stock – 19 October 2005

Daisuke Morioka, Mureo Kasahara, Yasutsugu Takada, Yasumasa Shirouzu, Kaoru Taira, Seisuke Sakamoto, Kenji Uryuhara, Hiroto Egawa, Hiroshi Shimada, Koichi Tanaka – 19 October 2005 – To address the current role of liver transplantation (LT) for urea cycle disorders (UCDs), we reviewed the worldwide English literature on the outcomes of LT for UCD as well as 13 of our own cases of living donor liver transplantation (LDLT) for UCD. The total number of cases was 51, including our 13 cases. The overall cumulative patient survival rate is presumed to be more than 90% at 5 years.

Andres T. Blei – 19 October 2005

Philippe Mathurin – 19 October 2005

Shushma Aggarwal, Walter Obrist, Howard Yonas, David Kramer, Yoogoo Kang, Victor Scott, Raymond Planinsic – 19 October 2005 – The purpose of this retrospective study was to examine the potential role of cerebral hemodynamic and metabolic factors in the outcome of patients with fulminant hepatic failure (FHF). Based on the literature, a hypothetical model was proposed in which physiologic changes progress sequentially in five phases, as defined by intracranial pressure (ICP) and cerebral blood flow (CBF) measurements.