Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: A comparison with nonalcoholics

Suthat Liangpunsakul, Dhanashri Kolwankar, Amar Pinto, J. Christopher Gorski, Stephen D. Hall, Naga Chalasani – 19 April 2005 – Alcohol consumption is known to induce hepatic CYP2E1 activity, but its effect on hepatic and intestinal CYP3A in humans is not known. We have conducted a study to compare the CYP2E1 and CYP3A activities in 20 individuals with moderate alcohol consumption and 20 gender‐, race‐. and body mass index (BMI)‐matched nonalcoholics.

Preferential loss of IL‐2–secreting CD4+ T helper cells in chronic HCV infection

Nasser Semmo, Cheryl L. Day, Scott M. Ward, Michaela Lucas, Gillian Harcourt, Andrew Loughry, Paul Klenerman – 19 April 2005 – Hepatitis C virus (HCV) becomes persistent in the majority of infected individuals. In doing so, the virus evades host adaptive immune responses, although the mechanisms responsible in this evasion are not clear. Several groups have demonstrated weak or absent HCV‐specific CD4+ T cell responses during chronic HCV infection using proliferation assays and, more recently, class II tetramers.

Natural history of hepatopulmonary syndrome: Impact of liver transplantation

Karen L. Swanson, Russell H. Wiesner, Michael J. Krowka – 19 April 2005 – Few data exist concerning survival after the diagnosis of hepatopulmonary syndrome (HPS). Although orthotopic liver transplantation (OLT) frequently results in complete resolution of HPS, the relationship between transplantation and survival has not been described. The study rationale was to describe long‐term survival in patients with HPS. Data were derived from patients diagnosed with HPS at Mayo Clinic (n = 61) between 1985 and 2002, including those undergoing OLT (n = 24) and those who did not (n = 37).

Hepatitis C virus core protein stimulates hepatocyte growth: Correlation with upregulation of wnt‐1 expression

Takayoshi Fukutomi, Yonghong Zhou, Shigenobu Kawai, Hidetoshi Eguchi, Jack R. Wands, Jisu Li – 19 April 2005 – Hepatitis C virus (HCV) core protein has been implicated in the development of human hepatocellular carcinoma (HCC). Here we report that expression of HCV core protein by transient transfection increased cell proliferation, DNA synthesis, and cell cycle progression in Huh‐7 cells, a human HCC‐derived cell line. Culture supernatant from transfected cells also harbored a growth‐promoting effect.

HIV coinfection shortens the survival of patients with hepatitis C virus‐related decompensated cirrhosis

Juan A. Pineda, Manuel Romero‐Gómez, Fernando Díaz‐García, José A. Girón‐González, José L. Montero, Julián Torre‐Cisneros, Raúl J. Andrade, Mercedes González‐Serrano, José Aguilar, Manuela Aguilar‐Guisado, José M. Navarro, Javier Salmerón, Francisco J. Caballero‐Granado, José A. García‐García – 30 March 2005 – The impact of human immunodeficiency virus (HIV) coinfection on the survival of patients with hepatitis C virus (HCV)‐related end‐stage liver disease (ESLD) is unknown.

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