Reply
Margarita Sala, Josep M. Llovet, Jordi Bruix – 24 March 2005
Reply:
Vincent Di Martino, Pascal Lebray, Thierry Poynard – 24 March 2005
Morphological and biochemical characterization of a human liver in a uPA‐SCID mouse chimera
Philip Meuleman, Louis Libbrecht, Rita De Vos, Bernard de Hemptinne, Kris Gevaert, Joël Vandekerckhove, Tania Roskams, Geert Leroux‐Roels – 24 March 2005 – A small animal model harboring a functional human liver cell xenograft would be a useful tool to study human liver cell biology, drug metabolism, and infections with hepatotropic viruses. Here we describe the repopulation, organization, and function of human hepatocytes in a mouse recipient and the infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) of the transplanted cells.
Is HFE involved in increased hepcidin expression and hypoferremia in inflammation and anemia of chronic disease?
Elizabeth A. Milward, Deborah Trinder, Chantelle E.J. Wilcox, Robert S. Britton, Grant A. Ramm, John K. Olynyk – 24 March 2005 – Inflammation influences iron balance in the whole organism. A common clinical manifestation of these changes is anemia of chronic disease (ACD; also called anemia of inflammation). Inflammation reduces duodenal iron absorption and increases macrophage iron retention, resulting in low serum iron concentrations (hyposideremia).
Persistence of antibody after hepatitis B vaccine and the question of boosters
Edward Tabor – 24 March 2005
Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection
Jeroen N. Stoop, Renate G. van der Molen, Carla C. Baan, Luc J. W. van der Laan, Ernst J. Kuipers, Johannes G. Kusters, Harry L. A. Janssen – 24 March 2005 – Chronic hepatitis B virus (HBV) infection is characterized by a weak immune response to HBV. Regulatory T cells (Treg) can suppress the function of effector T cells and may thus be key players in this impaired immune response. Changes in the functionality or number of Treg could explain the decreased antiviral response in chronic HBV patients.
Intermittent disconjugate gaze: A novel finding in nonalcoholic steatohepatitis and cryptogenic cirrhosis
Abdullah M. S. Al‐Osaimi, Carl L Berg, Stephen H. Caldwell – 24 March 2005
The crab, the turkey and a malignant tale from the year of the rooster
Adrian Reuben – 24 March 2005
Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy
Edward D. Javor, Marc G. Ghany, Elaine K. Cochran, Elif Arioglu Oral, Alex M. DePaoli, Ahalya Premkumar, David E. Kleiner, Phillip Gorden – 24 March 2005 – Severe lipodystrophy is characterized by diminished adipose tissue and hypoleptinemia, leading to ectopic triglyceride accumulation. In the liver, this is associated with steatosis, potentially leading to nonalcoholic steatohepatitis (NASH). We investigated the prevalence of NASH and the effect of leptin replacement in these patients.
Impact of hepatitis C on health related quality of life: A systematic review and quantitative assessment
Brennan M.R. Spiegel, Zobair M. Younossi, Ron D. Hays, Dennis Revicki, Sean Robbins, Fasiha Kanwal – 24 March 2005 – Hepatitis C virus (HCV) diminishes health related quality of life (HRQOL), and it is now common to measure HRQOL in clinical trials. We sought to summarize the HRQOL data in HCV, and to establish the minimally clinically important difference (MCID) in HRQOL scores in HCV. We performed a systematic review to identify relevant studies, and converted HRQOL data from each study into clinically interpretable statistics.