Preservation of the synthetic and metabolic capacity of isolated human hepatocytes by coculture with human biliary epithelial cells
Marcus K.H. Auth, Dirk Woitaschek, Mechthild Beste, Thomas Schreiter, Hyun Soo Kim, Elsie Oppermann, Ruth E. Joplin, Ulrich Baumann, Philip Hilgard, Silvio Nadalin, Bernd H. Markus, Roman A. Blaheta – 21 March 2005 – Bioartificial liver support systems have demonstrated limited efficacy in compensation of liver detoxification and substitution of liver‐derived factors. However, in these devices, the biological substitution of the complex liver function has been restricted to xenogeneic or transformed hepatocytes.