Simrat P. S. Saini, Ying Mu, Haibiao Gong, David Toma, Hirdesh Uppal, Songrong Ren, Song Li, Samuel M. Poloyac, Wen Xie – 22 February 2005 – The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are implicated in xenobiotic and endobiotic detoxification, including the clearance of toxic bilirubin. Previous studies have suggested both overlapping and preferential regulation of target genes by these receptors, but the mechanism of cross‐talk remains elusive.

Antony F. McDonagh – 22 February 2005

Turgay Çelik, M. Zafer Gören, Kubilay Çınar, Hakan Gürdal, F. Oğuz Önder, Akif Tan, Berna Terzioğlu, A. Mithat Bozdayı, Hakan Bozkaya, Özden Uzunalimoğlu, Cihan Yurdaydin – 22 February 2005 – Fatigue associated with cholestasis may impair health‐related quality of life. The pathogenesis of this symptom is largely unknown, but it has been suggested that central serotoninergic neurotransmission may be implicated and that serotonin 1A receptor agonists may yield improvement.

Masatoshi Kudo – 22 February 2005

Alan Lee Rothman, Chihiro Morishima, Herbert L. Bonkovsky, Stephen J. Polyak, Ranjit Ray, Adrian M. Di Bisceglie, Karen L. Lindsay, Peter F. Malet, Ming Chang, David R. Gretch, Daniel G. Sullivan, Atul K. Bhan, Elizabeth C. Wright, Margaret James Koziel – 22 February 2005 – The relationships among host immune and viral factors and the severity of liver disease due to hepatitis C virus (HCV) are poorly understood. Previous studies have focused on individual components of the immune response to HCV, often in relatively small numbers of patients.

Sandrine Boyault, Aurélie Hérault, Charles Balabaud, Jessica Zucman‐Rossi – 22 February 2005

Aftab Ala, Jimo Borjigin, Arnold Rochwarger, Michael Schilsky – 22 February 2005 – Wilson Disease (WD) usually presents in the first decades of life, although rare patients have a later presentation. We report the clincial features, diagnostic evaluation, and outcome with treatment of two septuagenarian siblings evaluated as part of a research trial for treatment of neurological WD. The index case was a 72‐year‐old woman who suffered progressive neurological disability, then developed sub‐fulminant liver failure.

Ann‐Sofi Duberg, Marie Nordström, Anna Törner, Olle Reichard, Reinhild Strauss, Ragnhild Janzon, Erik Bäck, Karl Ekdahl – 22 February 2005 – The aim of this study was to evaluate the association between hepatitis C virus (HCV) infection and non‐Hodgkin's lymphoma (NHL), multiple myeloma (MM), thyroid cancer (TC), chronic lymphatic leukemia (CLL), acute lymphatic leukemia (ALL), and Hodgkin's lymphoma (HL). A Swedish cohort of 27,150 HCV‐infected persons notified during 1990‐2000 was included in the study.

Simona Urbani, Carolina Boni, Barbara Amadei, Paola Fisicaro, Simona Cerioni, Maria Antonietta Valli, Gabriele Missale, Carlo Ferrari – 22 February 2005 – To characterize acute‐phase hepatitis B virus (HBV)‐specific T cell responses associated with self‐limited and persistent HBV infections, we compared a patient with acute HBV/HCV coinfection, who was able to control HCV but developed chronic hepatitis B, with patients who resolved acute HBV infection spontaneously.

Hui‐Ching Wang, Wen‐Tsan Chang, Wen‐Wei Chang, Han‐Chieh Wu, Wenya Huang, Huan‐Yao Lei, Ming‐Derg Lai, Nelson Fausto, Ih‐Jen Su – 22 February 2005 – Naturally occurring mutants with a deletion in the pre‐S2 region of the large surface protein (ΔS2‐LHBs) are prevalent in serum and livers of patients with chronic hepatitis B virus (HBV) infection associated with cirrhosis. The ΔS2‐LHBs protein is retained in the endoplasmic reticulum (ER) and may induce ER stress. One interesting observation is the consistently clustered distribution of hepatocytes expressing ΔS2‐LHBs.