Short‐term administration of (‐)‐epigallocatechin gallate reduces hepatic steatosis and protects against warm hepatic ischemia/reperfusion injury in steatotic mice

Ryan N. Fiorini, Jennifer L. Donovan, David Rodwell, Zachary Evans, Gang Cheng, Harold D. May, Charles E. Milliken, John S. Markowitz, Crystal Campbell, Julia K. Haines, Michael G. Schmidt, Kenneth D. Chavin – 17 February 2005 – Hepatic steatosis increases the extent of cellular injury incurred during ischemia/reperfusion (I/R) injury. (‐)‐Epigallocatechin gallate (EGCG), the major flavonoid component of green tea (camellia sinensis) is a potent antioxidant that inhibits fatty acid synthase (FAS) in vitro.

Safety of donor right hepatectomy without abdominal drainage: A prospective evaluation in 100 consecutive liver donors

Chi Leung Liu, Sheung Tat Fan, Chung Mau Lo, See Ching Chan, Boon Hun Yong, John Wong – 17 February 2005 – Although the role of routine abdominal drainage after liver resection for tumors has been questioned, abdominal drainage after donor right hepatectomy for live donor liver transplantation (LDLT) has been a routine practice in most transplant centers. The present study aimed to evaluate the safety of the procedure without abdominal drainage. A prospective study was performed on 100 consecutive liver donors who underwent right hepatectomy for LDLT from July 2000 to September 2003.

Addition of serum sodium into the MELD score predicts waiting list mortality better than MELD alone

Andres E. Ruf, Walter K. Kremers, Lila L. Chavez, Valeria I. Descalzi, Luis G. Podesta, Federico G. Villamil – 17 February 2005 – In this study, we investigated the prognostic value of serum sodium and hyponatremia (≤130 mEq/L) in 262 cirrhotic patients consecutively listed, 19 of which died (7%), 175 survived (67%), and 68 underwent liver transplantation (26%) during 3 months of follow‐up.

Improving the prediction of hepatocellular carcinoma in cirrhotic patients with an arterially‐enhancing liver mass

Jorge A. Marrero, Hero K. Hussain, Hahn V. Nghiem, Ramsey Umar, Robert J. Fontana, Anna S. Lok – 17 February 2005 – In the United States, cirrhotic patients with known or suspected hepatocellular carcinoma (HCC) are prioritized for liver transplantation. Noninvasive criteria for the diagnosis of HCC rely on arterial enhancement of a mass. The aim of this study was to determine whether clinical, laboratory, and / or radiologic data can improve the prediction of HCC in cirrhotic patients with an arterially‐enhancing mass.

Can a leukocyte depletion filter (LDF) reduce the risk of reintroduction of hepatocellular carcinoma cells?

Mi Sook Gwak, Kwang‐Woong Lee, Shi Yeon Kim, Jihyun Lee, Jae Won Joh, Sung Joo Kim, Hwan Hyo Lee, Jean Wan Park, Gaab Soo Kim, Suk‐Koo Lee – 17 February 2005 – During liver transplantation for hepatocellular carcinoma (HCC) patients, HCC could theoretically be introduced into the systemic circulation when salvaged blood is used with an autotransfusion device. Several reports have shown that some types of leukocyte depletion filters (LDFs) could completely reduce the risk for reintroducing some types of tumor cells.

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