How common is delayed cyclosporine absorption following liver transplantation?

Silvina E. Yantorno, Eva B. Varela, Sebastián R. Raffa, Valeria I. Descalzi, Maria L. Gomez Carretero, Daniel A. Pirola, Andres E. Ruf, Gretel I. Martinez Carabuz, Luis G. Podesta, Federico G. Villamil – 21 January 2005 – The mean time to peak absorption of cyclosporine (CsA) in liver transplant patients is approximately 2 hours, but in some patients the peak occurs later. The goal of this study was, therefore, to investigate the incidence of delayed absorption in 27 de novo liver transplant recipients receiving CsA ≥10 mg/kg/day (C2 monitoring) and in 15 maintenance patients.

Preharvest donor hyperoxia predicts good early graft function and longer graft survival after liver transplantation

Stefano Ginanni Corradini, Walter Elisei, Rosanna De Marco, Maria Siciliano, Massimo Iappelli, Francesco Pugliese, Franco Ruberto, Francesco Nudo, Renzo Pretagostini, Alessandro Bussotti, Gianluca Mennini, Annarita Eramo, Francesca Liguori, Manuela Merli, Adolfo Francesco Attili, Andrea Onetti Muda, Stefania Natalizi, Pasquale Berloco, Massimo Rossi – 21 January 2005 – A total of 44 donor/recipient perioperative and intraoperative variables were prospectively analyzed in 89 deceased‐donor liver transplantations classified as initial good graft function (IGGF) or initial poor graft function

Negative impact of systemic catecholamine administration on hepatic blood perfusion after porcine liver transplantation

Arianeb Mehrabi, Markus Golling, Arash Kashfi, Tamara Boucsein, Peter Schemmer, Carsten N. Gutt, Jan Schmidt, Markus W. Büchler, Thomas W. Kraus – 21 January 2005 – Catecholamines are often administered during and after liver transplantation (LTx) to support systemic perfusion and to increase organ oxygen supply. Some vasoactive agents can compromise visceral organ perfusion.

Presence of multiple bile ducts in the liver graft increases the incidence of biliary complications in pediatric liver transplantation

Paolo R.O. Salvalaggio, Peter F. Whitington, Estella M. Alonso, Riccardo A. Superina – 21 January 2005 – We studied the impact of multiple bile duct anastomosis on the development of biliary complications after liver transplantation in children. A total of 101 patients received a primary liver transplant and were divided into 2 groups: those with a single bile duct (n = 77) and those with multiple bile ducts (n = 24). Mean follow‐up was 39.8 ± 20.8 months.

Colonization with methicillin‐resistant Staphylococcus aureus after liver transplantation

Guilherme Santoro‐Lopes, Érika Ferraz de Gouvêa, Rodrigo Carreira M. Monteiro, Rodrigo Castelo Branco, José Rodolfo Rocco, Márcia Halpern, Adriana Lúcia Pires Ferreira, Elaine Gama Pessoa de Araújo, Samanta T. Basto, Vinicius Gomes Silveira, Joaquim Ribeiro‐Filho – 21 January 2005 – Methicillin‐resistant Staphylococcus aureus (MRSA) is a frequent cause of infection after orthotopic liver transplantation (OLT). Colonization with MRSA is associated with a higher risk of infection. Previous studies have shown a high prevalence of MRSA colonization among OLT candidates.

Amelioration of hypertrophic cardiomyopathy using nonsurgical septal ablation in a cirrhotic patient prior to liver transplantation

Anil S. Paramesh, Ralph B. Fairchild, Theresa M. Quinn, Fred Leya, Magdalene George, David H. Van Thiel – 21 January 2005 – A 53‐year‐old male with hepatitis C cirrhosis, who had been refused liver transplantation because of hypertrophic cardiomyopathy (HC), underwent nonsurgical septal ablation using alcohol with resolution of his ventricular outflow obstruction. This patient was able to subsequently undergo a successful deceased donor liver transplantation. This is the first reported case of alcohol induced septal ablation being performed in a cirrhotic patient with HC.

Ischemic preconditioning in deceased donor liver transplantation: A prospective randomized clinical trial of safety and efficacy

Baburao Koneru, Adrian Fisher, Yan He, Kenneth M. Klein, Joan Skurnick, Dorian J. Wilson, Andrew N. de la Torre, Anand Merchant, Rakesh Arora, Arun K. Samanta – 21 January 2005 – Ischemic preconditioning (IPC) has the potential to decrease graft injury and morbidity after liver transplantation. We prospectively investigated the safety and efficacy of 5 minutes of IPC induced by hilar clamping in local deceased donor livers randomized 1 : 1 to standard (STD) recovery (N = 28) or IPC (N = 34).

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