Jason M. Hui, Jacob George – 19 January 2005

Dimitri Lavillette, Alexander W. Tarr, Cécile Voisset, Peggy Donot, Birke Bartosch, Christine Bain, Arvind H. Patel, Jean Dubuisson, Jonathan K. Ball, François‐Loïc Cosset – 19 January 2005 – Because of the lack of a robust cell culture system, relatively little is known about the molecular details of the cell entry mechanism for hepatitis C virus (HCV). Recently, we described infectious HCV pseudo‐particles (HCVpp) that were generated by incorporating unmodified HCV E1E2 glycoproteins into the membrane of retroviral core particles.

Slaven Erceg, Pilar Monfort, Mariluz Hernández‐Viadel, Regina Rodrigo, Carmina Montoliu, Vicente Felipo – 19 January 2005 – Patients with liver disease with overt or minimal hepatic encephalopathy show impaired intellectual capacity. The underlying molecular mechanism remains unknown. Rats with portacaval anastomosis or with hyperammonemia without liver failure also show impaired learning ability and impaired function of the glutamate‐nitric oxide‐cyclic guanine monophosphate (glutamate‐NO‐cGMP) pathway in brain.

Karin Lindahl, Lars Stahle, Annette Bruchfeld, Robert Schvarcz – 19 January 2005 – Improved treatment regimens for patients with chronic hepatitis C, genotype 1 and high viral load are needed. Increasing the dose of ribavirin has increased the response rate, but experience with doses of more than 1,200 mg/day is limited. The aim of this study was to investigate the safety and tolerance to treatment with a high and individualized dose of ribavirin in combination with peginterferon.

Mark Davenport – 19 January 2005

Panayotis Lykavieris, Christophe Chardot, Maroun Sokhn, Frédéric Gauthier, Jacques Valayer, Olivier Bernard – 19 January 2005 – To define the long‐term prognosis of children undergoing the Kasai operation for biliary atresia, a retrospective study was undertaken comprising 271 patients operated between 1968 and 1983. Twenty years after surgery, 63 (23%) were alive with their native liver.

Ted A. Gooley, Pankaj Rajvanshi, H. Gary Schoch, George B. McDonald – 19 January 2005 – Many patients who undergo hematopoietic cell transplantation experience liver injury. We examined the association of serum bilirubin levels with nonrelapse mortality by day +200, testing the hypothesis that the duration of jaundice up to a given point in time provides more prognostic information than either the maximum bilirubin value or the value at that point in time. We studied 1,419 consecutive patients transplanted from allogeneic donors.

Osman Cavit Ozdogan – 19 January 2005

Barbara Akhurst, Vance Matthews, Kirsten Husk, Mark J. Smyth, Lawrence J. Abraham, George C. Yeoh – 19 January 2005 – The liver regenerates after acute injury via hepatocyte cell division; during chronic injury, when hepatocyte replication is impaired or blocked, liver progenitor oval cells mediate liver regeneration. If both regeneration options are blocked in animal models, then liver failure and death ensues. The mechanisms underlying oval cell induction, proliferation, and subsequent liver regeneration remain poorly characterized.

Lars Zender, Sebastian Hütker, Bettina Mundt, Morlen Waltemathe, Christian Klein, Christian Trautwein, Nisar P. Malek, Michael Peter Manns, Florian Kühnel, Stefan Kubicka – 19 January 2005 – Inhibition of NFκB enhances the susceptibility of cancer to TRAIL‐mediated apoptosis and is suggested as a strategy for cancer therapy. Because the role of NFκB in TRAIL‐mediated apoptosis of hepatocytes is unknown, we investigated the influence of NFκB‐inhibition in death ligand‐mediated apoptosis in hepatitis.