Albert J. Czaja, Francesco B. Bianchi, Herschel A. Carpenter, Edward L. Krawitt, Ansgar W. Lohse, Michael P. Manns, Ian G. McFarlane, Giorgina Mieli‐Vergani, Gotaro Toda, Diego Vergani, John Vierling, Mikio Zeniya – 23 December 2004 – New drugs and advances in molecular biology afford opportunities to upgrade the treatment of autoimmune hepatitis. The aims of this study were to define treatment problems, identify possible solutions, and stimulate investigations to improve patient care.

Anna S. F. Lok – 23 December 2004

James Neuberger – 23 December 2004

Valérie Paradis, Francoise Degos, Delphine Dargère, Nanou Pham, Jacques Belghiti, Claude Degott, Jean‐Louis Janeau, Annie Bezeaud, Dominique Delforge, Myriam Cubizolles, Ingrid Laurendeau, Pierre Bedossa – 23 December 2004 – Surface‐enhanced laser desorption ionization time‐of‐flight mass spectrometry (SELDI‐TOF MS) is a proteomic technique that enables the profiling of proteins present in any biological material studied. We used this approach to identify new biomarkers of hepatocellular carcinoma (HCC) in the sera of patients with cirrhosis.

Yasuhiko Kimura, Carlo Selmi, Patrick S. C. Leung, Tin K. Mao, Joseph Schauer, Mitchell Watnik, Shigeki Kuriyama, Mikio Nishioka, Aftab A. Ansari, Ross L. Coppel, Pietro Invernizzi, Mauro Podda, M. Eric Gershwin – 23 December 2004 – Epidemiological data suggest that environmental factors may trigger autoimmunity in genetically susceptible individuals. In primary biliary cirrhosis (PBC), it has been postulated that halogenated xenobiotics can modify self‐molecules, facilitating the breakdown of tolerance to mitochondrial antigens.

Scott J. Weston, Rachel L. Leistikow, K. Rajender Reddy, Maria Torres, Anne M. Wertheimer, David M. Lewinsohn, Sunwen Chou, Michael P. Davey, Christopher Corless, Cliona O'Farrelly, David R. Nelson, Hugo R. Rosen – 23 December 2004 – Hepatitis C virus (HCV)‐related liver failure is the leading indication for liver transplantation worldwide. After transplantation, virological recurrence is the rule, but the spectrum of histological injury is wide, ranging from the development of allograft cirrhosis within a few years to minimal hepatitis despite long‐term follow‐up.

Jae‐Koo An, Keith Blomenkamp, Douglas Lindblad, Jeffrey H. Teckman – 23 December 2004 – Alpha‐1‐antitrypsin (α1AT) deficiency in its most common form is caused by homozygosity for the α1AT mutant Z gene. This gene encodes a mutant Z secretory protein, primarily synthesized in the liver, that assumes an abnormal conformation and accumulates within hepatocytes causing liver cell injury. Studies have shown that mutant α1ATZ protein molecules form unique protein polymers.

Laetitia Fartoux, Olivier Chazouillères, Dominique Wendum, Raoul Poupon, Lawrence Serfaty – 23 December 2004 – In patients with mild hepatitis C, the usefulness of antiviral therapy is subject of debate, as a low risk for progression of fibrosis is assumed. Several studies have shown that steatosis is a strong and independent predictor of the severity as well as the progression of fibrosis in chronic hepatitis C. Therefore, this study assessed the impact of steatosis on the progression of fibrosis between paired liver biopsies in untreated patients with mild hepatitis on index biopsy.

Alphonse E. Sirica – 23 December 2004 – Cholangiocarcinomas are devastating cancers that are increasing in both their worldwide incidence and mortality rates. The challenges posed by these often lethal biliary tract cancers are daunting, with conventional treatment options being limited and the only hope for long‐term survival being that of complete surgical resection of the tumor. Unfortunately, the vast majority of patients with cholangiocarcinoma typically seek treatment with advanced disease, and often these patients are deemed poor candidates for curative surgery.

Jelica Kurtovic, Qing Liu, Zhong Ping Duan, Da Kang Ha, Stig Bengmark, Stephen M. Riordan – 23 December 2004