Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol‐induced oxidative DNA damage in rodent liver

Blair U. Bradford, Hiroshi Kono, Fuyumi Isayama, Oksana Kosyk, Michael D. Wheeler, Taro E. Akiyama, Lisa Bleye, Kristopher W. Krausz, Frank J. Gonzalez, Dennis R. Koop, Ivan Rusyn – 19 January 2005 – The occurrence of malignant tumors of the upper gastrointestinal tract and liver is, based largely on epidemiological evidence, causally related to the consumption of ethanol. It is widely recognized that oxidants play a key role in alcohol‐induced liver injury; however, it is unclear how oxidants may be involved in DNA damage.

Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis

Eduardo Schiffer, Chantal Housset, Wulfran Cacheux, Dominique Wendum, Christèle Desbois‐Mouthon, Colette Rey, François Clergue, Raoul Poupon, Véronique Barbu, Olivier Rosmorduc – 19 January 2005 – Epidermal growth factor receptor (EGFR) binds transforming growth factor α (TGF‐α) which is mitogenic for hepatocytes. Diverse lines of evidence suggest that activation of the TGF‐α /EGFR pathway contributes to hepatocellular carcinoma (HCC) formation.

Nosocomial transmission of HCV in the liver unit of a tertiary care center

Xavier Forns, Eva Martínez‐Bauer, Anna Feliu, Montserrat García‐Retortillo, Marta Martín, Eugeni Gay, Miquel Navasa, Jose María Sánchez‐Tapias, Miquel Bruguera, Juan Rodés – 23 December 2004 – Despite its medical and legal implications, there are no prospective studies analyzing the incidence and mechanisms involved in the nosocomial transmission of hepatitis C virus (HCV) in liver units. This study prospectively investigates the nosocomial transmission of HCV in the liver unit of a tertiary care center from August 2000 to October 2002.

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