Grace L. Su, Ke Qin Gong, Ming Hui Fan, William M. Kelley, Jason Hsieh, Jian Min Sun, Mark R. Hemmila, Saman Arbabi, Daniel G. Remick, Stewart C. Wang – 23 December 2004 – Acetaminophen toxicity is the most common cause of acute liver failure in the United States and Europe. Although much is known about the metabolism of acetaminophen, many questions remain regarding the pathogenesis of liver injury.
Katsunori Shinozaki, Oliver Ebert, Savio L.C. Woo – 23 December 2004 – Viruses that replicate selectively in cancer cells hold considerable promise as novel therapeutic agents for the treatment of malignancy. Vesicular stomatitis virus (VSV) is a nonpathogenic RNA virus with intrinsic oncolytic specificity due to attenuated antiviral responses in many tumors.
Ayako Suzuki, Paul Angulo, James Lymp, Jennifer St. Sauver, Ayako Muto, Toshihide Okada, Keith Lindor – 23 December 2004 – The incidence and risk factors of nonalcoholic fatty liver disease (NAFLD) have never been prospectively determined. To determine the frequency and risk factors of NAFLD and chronological ordering between NAFLD, weight gain, and features of insulin resistance, a historical cohort study was conducted in a Japanese workplace.
Marianne Ziol, Adriana Handra‐Luca, Adrien Kettaneh, Christos Christidis, Frédéric Mal, Farhad Kazemi, Victor de Lédinghen, Patrick Marcellin, Daniel Dhumeaux, Jean‐Claude Trinchet, Michel Beaugrand – 23 December 2004 – Liver fibrosis is the main predictor of the progression of chronic hepatitis C, and its assessment by liver biopsy (LB) can help determine therapy. However, biopsy is an invasive procedure with several limitations. A new, noninvasive medical device based on transient elastography has been designed to measure liver stiffness.
Richard H. Moseley – 23 December 2004 – Sahai A, Malladi P, Melin‐Aldana H, Green RM, Whitington PF. Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model. Am J Physiol Gastrointest Liver Physiol 2004;287:G264‐G273. (Reprinted with permission of American Physiological Society)
Astrid Kosters, Raoul J. J. M. Frijters, Cindy Kunne, Edwin Vink, Marit S. Schneiders, Frank G. Schaap, Catherina P. Nibbering, Shailendra B. Patel, Albert K. Groen – 23 December 2004 – The plant sterol diosgenin has been shown to stimulate biliary cholesterol secretion in mice without affecting the expression of the adenosine triphosphate‐binding cassette transporter heterodimer Abcg5/g8. The aim of this study was to investigate the mechanism of diosgenin‐induced cholesterol hypersecretion and to identify the genes involved.
Shruti H. Mehta, David L. Thomas, Michael Torbenson, Sherilyn Brinkley, Lisa Mirel, Richard E. Chaisson, Richard D. Moore, Mark S. Sulkowski – 23 December 2004 – In the era of antiretroviral therapy (ART), liver disease has emerged as an important cause of death among persons with human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfection. The objective of this study was to estimate the burden of liver disease and evaluate determinants of liver fibrosis and necroinflammatory activity among HIV/HCV coinfected patients receiving ART.
Nick Shackel, Don Rockey – 23 December 2004
Harvey J. Alter – 23 December 2004
Kazuo Ohashi, Jacob M. Waugh, Michael D. Dake, Takashi Yokoyama, Hiroyuki Kuge, Yoshiyuki Nakajima, Masaki Yamanouchi, Hiroyuki Naka, Akira Yoshioka, Mark A. Kay – 23 December 2004 – Liver tissue engineering using hepatocyte transplantation has been proposed as an alternative to whole‐organ transplantation or liver‐directed gene therapy to correct various types of hepatic insufficiency. Hepatocytes are not sustained when transplanted under the kidney capsule of syngeneic mice.