Serum bilirubin levels and mortality after myeloablative allogeneic hematopoietic cell transplantation

Ted A. Gooley, Pankaj Rajvanshi, H. Gary Schoch, George B. McDonald – 19 January 2005 – Many patients who undergo hematopoietic cell transplantation experience liver injury. We examined the association of serum bilirubin levels with nonrelapse mortality by day +200, testing the hypothesis that the duration of jaundice up to a given point in time provides more prognostic information than either the maximum bilirubin value or the value at that point in time. We studied 1,419 consecutive patients transplanted from allogeneic donors.

Outcome in adulthood of biliary atresia: A study of 63 patients who survived for over 20 years with their native liver

Panayotis Lykavieris, Christophe Chardot, Maroun Sokhn, Frédéric Gauthier, Jacques Valayer, Olivier Bernard – 19 January 2005 – To define the long‐term prognosis of children undergoing the Kasai operation for biliary atresia, a retrospective study was undertaken comprising 271 patients operated between 1968 and 1983. Twenty years after surgery, 63 (23%) were alive with their native liver.

High‐dose ribavirin in combination with standard dose peginterferon for treatment of patients with chronic hepatitis C

Karin Lindahl, Lars Stahle, Annette Bruchfeld, Robert Schvarcz – 19 January 2005 – Improved treatment regimens for patients with chronic hepatitis C, genotype 1 and high viral load are needed. Increasing the dose of ribavirin has increased the response rate, but experience with doses of more than 1,200 mg/day is limited. The aim of this study was to investigate the safety and tolerance to treatment with a high and individualized dose of ribavirin in combination with peginterferon.

Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts

Slaven Erceg, Pilar Monfort, Mariluz Hernández‐Viadel, Regina Rodrigo, Carmina Montoliu, Vicente Felipo – 19 January 2005 – Patients with liver disease with overt or minimal hepatic encephalopathy show impaired intellectual capacity. The underlying molecular mechanism remains unknown. Rats with portacaval anastomosis or with hyperammonemia without liver failure also show impaired learning ability and impaired function of the glutamate‐nitric oxide‐cyclic guanine monophosphate (glutamate‐NO‐cGMP) pathway in brain.

Characterization of host‐range and cell entry properties of the major genotypes and subtypes of hepatitis C virus

Dimitri Lavillette, Alexander W. Tarr, Cécile Voisset, Peggy Donot, Birke Bartosch, Christine Bain, Arvind H. Patel, Jean Dubuisson, Jonathan K. Ball, François‐Loïc Cosset – 19 January 2005 – Because of the lack of a robust cell culture system, relatively little is known about the molecular details of the cell entry mechanism for hepatitis C virus (HCV). Recently, we described infectious HCV pseudo‐particles (HCVpp) that were generated by incorporating unmodified HCV E1E2 glycoproteins into the membrane of retroviral core particles.

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