Eduardo Schiffer, Chantal Housset, Wulfran Cacheux, Dominique Wendum, Christèle Desbois‐Mouthon, Colette Rey, François Clergue, Raoul Poupon, Véronique Barbu, Olivier Rosmorduc – 19 January 2005 – Epidermal growth factor receptor (EGFR) binds transforming growth factor α (TGF‐α) which is mitogenic for hepatocytes. Diverse lines of evidence suggest that activation of the TGF‐α /EGFR pathway contributes to hepatocellular carcinoma (HCC) formation.

Blair U. Bradford, Hiroshi Kono, Fuyumi Isayama, Oksana Kosyk, Michael D. Wheeler, Taro E. Akiyama, Lisa Bleye, Kristopher W. Krausz, Frank J. Gonzalez, Dennis R. Koop, Ivan Rusyn – 19 January 2005 – The occurrence of malignant tumors of the upper gastrointestinal tract and liver is, based largely on epidemiological evidence, causally related to the consumption of ethanol. It is widely recognized that oxidants play a key role in alcohol‐induced liver injury; however, it is unclear how oxidants may be involved in DNA damage.

Ronald J. Sokol, Cara L. Mack – 19 January 2005

Mario Chojkier – 19 January 2005

Naga Chalasani, Cosme Manzarbeitia, Peter Ferenci, Wolfgang Vogel, Robert J. Fontana, Michael Voigt, Caroline Riely, Paul Martin, Lewis Teperman, James Jiao, Juan Carlos Lopez‐Talavera – 19 January 2005 – There is currently no effective treatment for recurrent hepatitis C after orthotopic liver transplantation (OLT). We therefore performed two randomized, controlled trials—a prophylaxis trial and a treatment trial—to evaluate the safety and efficacy of peginterferon alfa‐2a in patients who had undergone OLT.

Neil Kaplowitz – 19 January 2005

Chih‐Hao Lin, Shyr‐Chyr Chen, Patrick Chow‐In Ko – 19 January 2005

Shiobhan R. Weston, Wendy Leyden, Rose Murphy, Nathan M. Bass, Beth P. Bell, M. Michele Manos, Norah A. Terrault – 19 January 2005 – We performed a cross‐sectional study of newly diagnosed cases of nonalcoholic fatty liver disease (NAFLD) identified between December 1998 and December 2000 in the Chronic Liver Disease Surveillance Study. We compared the demographic and clinical features of NAFLD in a racially diverse representative U.S. population (Alameda County, CA).

Paul B. Watkins – 19 January 2005

Rahul A. Nathwani, Shireen Pais, Telfer B. Reynolds, Neil Kaplowitz – 19 January 2005 – Although elevation of the levels of serum alanine aminotransferase (ALT) following liver injury is well known, confusion exists concerning skeletal muscle injury as the cause of this rise. We reviewed the records of 16 patients who had muscle necrosis without evidence of liver disease. The patients were divided into three groups: extreme exercise, polymyositis, and seizures. All patients exhibited markedly elevated creatine kinase and lactate dehydrogenase levels consistent with muscle injury.