Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide

Aparna Venkatraman, Sruti Shiva, Ashley J. Davis, Shannon M. Bailey, Paul S. Brookes, Victor M. Darley‐Usmar – 30 December 2003 – Chronic alcohol consumption is a well‐known risk factor for hepatic injury, and mitochondrial damage plays a significant role in this process. Nitric oxide (NO) is an important modulator of mitochondrial function and is known to inhibit mitochondrial respiration. However, the impact of chronic alcohol consumption on NO‐dependent control of liver mitochondrial function is unknown.

Liver transplantation with hepatitis C virus‐infected graft: Interaction between donor and recipient viral strains

Xiaofeng Fan, Dorothy M. Lang, Yanjuan Xu, Andre C. Lyra, Karina Yusim, James E. Everhart, Bette T. M. Korber, Alan S. Perelson, Adrian M. Di Bisceglie – 30 December 2003 – Superinfection of different viral strains within a single host provides an opportunity for studying host‐virus and virus‐virus interactions, including viral interference and genetic recombination, which cannot be studied in infections with single viral strains. Hepatitis C virus (HCV) is a positive single‐strand RNA virus that establishes persistent infection in as many as 85% of infected individuals.

Effect of ribavirin on hepatitis C viral kinetics in patients treated with pegylated interferon

Eva Herrmann, Jung‐Hun Lee, George Marinos, Marlene Modi, Stefan Zeuzem – 30 December 2003 – A dynamic equilibrium between viral production and clearance characterizes untreated chronic hepatitis C viral infection. After initiating antiviral treatment, a typical multiphasic decay of viremia can be observed and analyzed using mathematical models.

Sonographic criteria for the diagnosis of hepatic involvement in hereditary hemorrhagic telangiectasia (HHT)

Martin Caselitz, Matthias J. Bahr, Jörg S. Bleck, Ajay Chavan, Michael P. Manns, Siegfried Wagner, Michael Gebel – 30 December 2003 – Hepatic involvement in hereditary hemorrhagic telangiectasia (HHT) is highly variable and may lead to severe clinical symptoms such as heart failure. This controlled, prospective study defined sonographic criteria for hepatic involvement in HHT.

Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis

Giovanni Musso, Roberto Gambino, Franco De Michieli, Maurizio Cassader, Mario Rizzetto, Marilena Durazzo, Emanuela Fagà, Barbara Silli, Gianfranco Pagano – 30 December 2003 – The relations of dietary habits to insulin sensitivity and postprandial triglyceride metabolism were evaluated in 25 patients with nonalcoholic steatohepatitis (NASH) and 25 age‐, body mass index (BMI)‐, and gender‐matched healthy controls.

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