Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide
Aparna Venkatraman, Sruti Shiva, Ashley J. Davis, Shannon M. Bailey, Paul S. Brookes, Victor M. Darley‐Usmar – 30 December 2003 – Chronic alcohol consumption is a well‐known risk factor for hepatic injury, and mitochondrial damage plays a significant role in this process. Nitric oxide (NO) is an important modulator of mitochondrial function and is known to inhibit mitochondrial respiration. However, the impact of chronic alcohol consumption on NO‐dependent control of liver mitochondrial function is unknown.