Hepatocyte lineages: Of clones, streams, patches, and nodules in the liver
Joe W. Grisham – 30 December 2003
Repolarization of hepatocytes in culture
M. A. Talamini, B. Kappus, A. Hubbard – 30 December 2003 – We have evaluated the biochemical, morphological, and functional redevelopment of polarity in freshly isolated hepatocytes cultured using a double layer collagen gel sandwich technique. Western blot analysis showed increased cellular levels of the cell adhesion protein uvomorulin as cultured hepatocytes repolarized.
The relationship between iron overload, clinical symptoms, and age in 410 patients with genetic hemochromatosis
P. C. Adams, Y. Deugnier, R. Moirand, P. Brissot – 30 December 2003 – The aim of this study was to investigate the relationship between iron overload, age, and clinical symptoms in genetic hemochromatosis. The relationship was studied between clinical symptoms and liver iron concentration, serum ferritin, and iron removed in a retrospective study of 410 homozygotes diagnosed using strict criteria. No significant relationship was found between liver iron concentration, iron removed by venesection, and serum ferritin level with age.
Total volume paracentesis decreases variceal pressure, size, and variceal wall tension in cirrhotic patients
D. Kravetz, G. Romero, J. Argonz, M. Guevara, A. Suarez, R. Abecasis, M. Bildozola, J. Valero, R. Terg – 30 December 2003 – It has been suggested that ascites is a risk factor for variceal bleeding in cirrhotic patients. However, no data of total volume paracentesis (TVP) effects on variceal hemodynamics has yet been published. The aim of this study was to investigate the effects of TVP on variceal pressure, size, and tension in cirrhotic patients. Before sclerotherapy, 18 cirrhotic patients with grade II esophageal varices were studied.
Living donor liver transplantation in patients with chronic hepatitis C: Timing is everything
Mitchell L. Shiffman – 30 December 2003
Retransplantation for recurrent hepatitis C: The argument against
William J. Wall, Anand Khakhar – 30 December 2003 – Key points
Retransplantation for recurrent hepatitis C: Positive aspects
Timothy M. McCashland – 30 December 2003 – Key points
Liver biopsy, viral kinetics, and the impact of viremia on severity of hepatitis C virus recurrence
Michael Charlton – 30 December 2003 – Key points
A potent and specific morpholino antisense inhibitor of hepatitis C translation in mice
Anton P. McCaffrey, Leonard Meuse, Mobin Karimi, Christopher H. Contag, Mark A. Kay – 30 December 2003 – Hepatitis C virus (HCV) is an RNA virus infecting one in every 40 people worldwide. Current treatments are ineffective and HCV is the leading cause of liver failure leading to transplantation in the United States and Europe. Translational control of HCV is a prime therapeutic target.
Cellular retinol‐binding protein‐1 in hepatocellular carcinoma correlates with β‐catenin, Ki‐67 index, and patient survival
Annette Schmitt‐Gräff, Viktoria Ertelt, Hans‐P. Allgaier, Konrad Koelble, Manfred Olschewski, Roland Nitschke, Marie‐L. Bochaton‐Piallat, Giulio Gabbiani, Hubert E. Blum – 30 December 2003 – The cellular retinol‐binding protein‐1 (CRBP‐1) plays a key role in the esterification and intercellular transfer of retinol. By in situ hybridization, immunohistochemistry, and confocal laser scanning microscopy (CLSM), we show that, in normal liver, CRBP‐1 is strongly expressed in the cytoplasm of hepatic stellate cells (HSCs) and myofibroblasts (MFs) with only low CRBP‐1 levels in hepatocytes.