Biliary excretion of estradiol‐17β‐glucuronide in the rat

H Takikawa, R Yamazaki, N Sano, M Yamanaka – 1 March 1996 – Estradiol‐17β‐glucuronide (E217G) is a cholestatic agent and is considered to be related to the pathogenesis of intrahepatic cholestasis of pregnancy. In the current study, we examined the mechanism of the biliary excretion of E217G and estradiol metabolites in rats. Biliary excretion of tracer doses of [3H]estradiol‐17β‐glucuronide and [14C]estradiol or [3H]taurocholate and ]14C]vinblastine, a P‐glycoprotein (P‐GP) substrate, intravenously administered as a bolus to bile‐drained control rats or EHBR was studied.

Changes in rat liver gene expression induced by thioacetamide: Protective role of S‐adenosyl‐L‐methionine by a glutathione‐dependent mechanism

M L Mesa, R Carrizosa, C Martinez‐Honduvilla, M Benito, I Fabregat – 1 March 1996 – Chronic liver damage induced by thioacetamide (TAM) was accompanied by changes in the expression of genes related to growth (β‐actin) and function (albumin and haptoglobin) of the liver. Their messenger RNA (mRNA) levels increased during the first days after TAM administration, but 4 to 7 days after prolonged treatment with this drug, liver gene expression was considerable decreased. TAM‐induced changes in albumin and β‐actin mRNA levels were prevented by cotreatment with S‐adenosyl‐L‐methionine (SAM).

Studies of liver repopulation using the dipeptidyl peptidase IV‐deficient rat and other rodent recipients: Cell size and structure relationships regulate capacity for increased transplanted hepatocyte mass in the liver lobule

P Rajvanshi, A Kerr, K K Bhargava, R D Burk, S Gupta – 1 March 1996 – The feasibility of liver repopulation with hepatocytes has been shown, although clinical applications demand significant hepatic replacement. To show whether portal vascular bed in large animals could accomodate a greater cell number, we analyzed liver repopulation in syngeneic Fischer 344 rats deficient in dipeptidyl peptidase IV. This system allowed localization of transplanted normal hepatocytes in liver or various ectopic sites, as well as dual studies for analysis of gene expression.

Transjugular intrahepatic portosystemic shunt in patients with end‐stage liver disease: Results in 85 patients

Nicolas Jabbour, Albert B. Zajko, Philip D. Orons, William Irish, Fabio Bartoli, Wallis J. Marsh, Gerald D. Dodd, Luca Aldreghitti, Joann Colangelo, Jorge Rakela, John J. Fung – 1 March 1996 – Transjugular intrahepatic portosystemic shunt (TIPS) is becoming an accepted procedure as a bridge to orthotopic liver transplantation (OLT) in patients with end‐stage liver disease (ESLD) and bleeding from portal hypertension. It allows the immediate control of acute bleeding and decreases the risk of recurrent acute bleeding while the patient is awaiting OLT.

Release of soluble intercellular adhesion molecule 1 into bile and serum in murine endotoxin shock

H Jaeschke, N A Essani, M A Fisher, S L Vonderfecht, A Farhood, C W Smith – 1 March 1996 – Neutrophil‐induced liver injury during endotoxemia is dependent on the adhesion molecules Mac‐1 (CD11b/CD18) on neutrophils and its counterreceptor on endothelial cells and hepatocytes, intercellular adhesion molecule 1 (ICAM‐1). To investigate a potential release of a soluble form of ICAM‐1 (sICAM‐1), animals received 100 μg/kg Salmonella abortus equi endotoxin alone or in combination with 700 mg/kg galactosamine.

Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor

M Mise, S Arii, H Higashituji, M Furutani, M Niwano, T Harada, S Ishigami, Y Toda, H Nakayama, M Fukumoto, J Fujita, M Imamura – 1 March 1996 – Hepatocellular carcinoma (HCC) is a typical hypervascular tumor. However, the relationship between the vascularity of HCC and the expression of angiogenic factors has not been investigated. In addition, no detailed studies have examined the possible involvement of angiogenic factors in the grade of malignancy of HCC.

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