I Sakaida, Y Matsumura, M Kubota, K Kayano, K Takenaka, K Okita – 1 April 1996 – No effective therapy has yet developed for liver fibrosis by directory inhibiting the accumulation of extracellular matrix. The effect of a newly synthesized prolyl4‐hydroxylase (PH) inhibitor, HOE 077 (pyridine‐ 2, 4‐di‐carboxylic‐di(2‐methoxyethyl)amide), was examined using the model of choline‐deficient L‐amino acid (CDAA) defined diet‐induced liver fibrosis in 16‐week‐old male Wistar rats.

S Langouet, F Morel, D J Meyer, O Fardel, L Corcos, B Ketterer, A Guillouzo – 1 April 1996 – Recently, we used human hepatocytes in primary culture to study the effects of inducers of glutathione‐S‐transferases (GSTs) in the expectation that information obtained can be used to predict the value of particular inducers for use in the chemoprevention of cancer and other toxicities. However, in vitro human studies cannot readily be confirmed by studies in vivo. This problem does not arise in experimental animals.

H P Friedman, J D Goldberg – 1 April 1996

S Mondro – 1 April 1996

T Körner, J Kropf, R Hackler, A Brenzel, A M Gressner – 1 March 1996 – In a preliminary study, we demonstrated a strong association between the concentration of the glycoprotein fibronectin (FN) in human bile fluid and the presence of malignant biliary diseases. We now present the results of measurements of total FN (tFN) and cellular FN (cFN) within a larger group of 71 patients. Bile fluid was collected during routine endoscopic retrograde cholangiography or by transhepatic puncture, respectively, from patients admitted for examination/treatment of biliary obstruction.

P Pellinen, F Stenback, A Kojo, P Honkakoski, H V Gelboin, M Pasanen – 1 March 1996 – The effects of daily cocaine administration for up to 14 days were studied in terms of hepatic morphology and the expression of cytochrome P450 (CYP) enzymes in the mouse liver. Daily intraperitoneal doses of 60 mg/kg of cocaine for 3 days induced severe hepatocellular necrosis in the pericentral zone and decreased activities of CYP1A2, CYP2A4/5, and CYP2Cx.

F Mion, A Géloén, E Agosto, Y Minaire – 1 March 1996 – In animal models, conflicting results on the effect of cirrhosis on glucose metabolism have been reported. The use of various toxins as well as differences in experimental protocols may be responsible for these controversial data. However, differences may be also be explained by the fact that glucose metabolism has been evaluated following different time intervals after cessation of the toxic injury.

R Dumaswala, D Berkowitz, J E Heubi – 1 March 1996 – Experimental cholestasis induced by ligation of the common bile duct results in morphological and functional changes in the rat hepatocyte. The aim of this study was to evaluate the adaptive response of the transport process involved in the enterohepatic circulation of bile salts to obstructive cholestasis. Male Sprague‐dawley rats with common bile duct ligation were killed after 48 and 72 hours. Portal and systemic blood and duodenal aspirates were collected.

John S. Radomski, Michael J. Moritz, Vincent T. Armenti, Santiago J. Muñoz – 1 March 1996

Martin Hertl, Todd K. Howard, Jeffrey A. Lowell, Surendra Shenoy, P. Robert C. Harvey, Steven M. Strasberg – 1 March 1996 – Liver core temperature during organ procurement, storage, and rewarming has not been reported in human orthotopic liver transplantations (OLT). We have shown in the rat that optimal temperature for liver storage is not 4°C but 0°C to 1°C. Therefore, a study was undertaken in humans and in pigs to determine the pattern of temperature change during OLT.