John S. Radomski, Michael J. Moritz, Vincent T. Armenti, Santiago J. Muñoz – 1 March 1996

R Dumaswala, D Berkowitz, J E Heubi – 1 March 1996 – Experimental cholestasis induced by ligation of the common bile duct results in morphological and functional changes in the rat hepatocyte. The aim of this study was to evaluate the adaptive response of the transport process involved in the enterohepatic circulation of bile salts to obstructive cholestasis. Male Sprague‐dawley rats with common bile duct ligation were killed after 48 and 72 hours. Portal and systemic blood and duodenal aspirates were collected.

F Mion, A Géloén, E Agosto, Y Minaire – 1 March 1996 – In animal models, conflicting results on the effect of cirrhosis on glucose metabolism have been reported. The use of various toxins as well as differences in experimental protocols may be responsible for these controversial data. However, differences may be also be explained by the fact that glucose metabolism has been evaluated following different time intervals after cessation of the toxic injury.

P Pellinen, F Stenback, A Kojo, P Honkakoski, H V Gelboin, M Pasanen – 1 March 1996 – The effects of daily cocaine administration for up to 14 days were studied in terms of hepatic morphology and the expression of cytochrome P450 (CYP) enzymes in the mouse liver. Daily intraperitoneal doses of 60 mg/kg of cocaine for 3 days induced severe hepatocellular necrosis in the pericentral zone and decreased activities of CYP1A2, CYP2A4/5, and CYP2Cx.

T Körner, J Kropf, R Hackler, A Brenzel, A M Gressner – 1 March 1996 – In a preliminary study, we demonstrated a strong association between the concentration of the glycoprotein fibronectin (FN) in human bile fluid and the presence of malignant biliary diseases. We now present the results of measurements of total FN (tFN) and cellular FN (cFN) within a larger group of 71 patients. Bile fluid was collected during routine endoscopic retrograde cholangiography or by transhepatic puncture, respectively, from patients admitted for examination/treatment of biliary obstruction.

E Mawet, Y Shiratori, Y Hikiba, H Takada, H Yoshida, K Okano, Y Komatsu, M Matsumura, Y Niwa, M Omata – 1 February 1996 – To clarify the role of intercellular communication in the liver during accumulation of neutrophils, the release of cytokine‐induced neutrophil chemoattractant (CINC) (interleukin‐8 [IL‐8] related protein in rodents) by hepatocytes was investigated in the presence of Kupffer cell‐conditioned medium in vitro.

M Sasaki, T Morita, M Hoso, Y Nakanuma, H Tanimura – 1 February 1996 – We investigated whether carbohydrate antigens on biliary glycoproteins and carcinoembryonic antigen (CEA) are related to hepatolithiasis.

D A Brenner – 1 February 1996

M Guido, S N Thung – 1 February 1996

K Ogasawara, J Uchino, Y Une, Y Fujioka – 1 February 1996 – Portal vein embolization has been used recently to decrease the amount of the liver to be resected and to enhance the function of the remaining hypertrophied lobes. We have observed a strong contact destructivity of absolute ethanol and used it for portal vein embolization. The present study was performed to produce hepatic hypertrophy and to show histopathologic changes that follow ethanol embolization of rat liver.