Y Pirson, N Lannoy, D Peters, A Geubel, J Gigot, M Breuning, C Verellen‐Dumoulin – 1 February 1996 – Polycystic liver disease (PLD) is proven to occur either sporadically or in association with autosomal dominant polycystic kidney disease (ADPKD), whereas the existence of an isolated (i.e., without any kidney cyst) familial form is disputed. We describe a family with definitely isolated PLD transmitted through three generations and exclude the linkage of the disease to the genetic markers of PKD1 and PKD2, the two main loci responsible for ADPKD.

C Barriault, J Petit, M Gascon‐Barre, P Huet, I M Yousef, B Tuchweber – 1 February 1996 – In this study, the possible role of the hepatic microcirculation in phalloidin‐induced cholestasis and hepatotoxicity was examined in isolated perfused rat livers (IPRL). Administration of a phalloidin bolus (1 mg/kg body weight) through the portal vein induced an immediate reduction of bile flow. In 16.9 minutes, bile flow was 50% lower than basal values.

T Matsuda, H Morita, H Hosomi, M Okada – 1 February 1996 – Hepatic sensory systems are thought to play an important role in the response of renal nerve activity and natriuresis to oral NaCl load. In this study, responses of renal nerve activity and urinary Na+ and Cl− excretions to a high‐NaCl food intake (20 g/kg boiled rice containing 0.4 g/kg NaCl) were examined in sham‐operated dogs (n = 12) and dogs with chronic bile duct ligation (CBDL; n = 10).

K V Kowdley, A S Tavill – 1 February 1996

T Imamura, T Tanahashi – 1 February 1996 – Although fibroblast growth factor 1 (FGF‐1) (formerly known as acidic FGF) but not FGF‐2 (or basic FGF), has been suggested to play a pathophysiological role in liver regeneration, its clinical application has been restricted by its limited mitogenecity and heparin dependence. We report here that a chimeric human FGF protein, FGF‐C(1211), is a heparin‐independent potent mitogen for liver parenchymal cells both in vitro and in vivo.

A D Branch – 1 February 1996

Y K Shimizu, S M Feinstone, M Kohara, R H Purcell, H Yoshikura – 1 February 1996 – We previously demonstrated that a human T‐cell line, HPBMa10‐2 derived from HPBALL, was capable of supporting a productive infection of hepatitis C virus (HCV). We subsequently found Daudi cells, a human B‐cell line, to be susceptible to HCV infection. Employing these cell lines infected with HCV as well as liver obtained during the acute phase of hepatitis C from a chimpanzee, we observed intracellular HCV particles by electron microscopy (EM).

J Kountouras, I Magoula, G Tsapas, I Liatsis – 1 February 1996 – No evidence is available on the transport of biliary urate and the possible role of choleretic agents in the regulation of biliary urate elimination in humans.

1 February 1996

1 February 1996