Y Lin, R Havinga, H J Verkade, H Moshage, M J Slooff, R J Vonk, F Kuipers – 1 February 1996 – The existence of a relationship between bile acid and triacylglycerol metabolism in humans has been established, but the underlying mechanism and its physiological relevance have remained unclear. We have studied the effects of bile acids on the secretion of very‐low‐density lipoprotein (VLDL)‐associated triacylglycerol, using [3H]glycerol labeling technique, and apolipoprotein B (apoB) in human hepatocytes in primary culture.

J Wu, H Soderbergh, K Karlsson, Å Danielsson – 1 February 1996 – The protective effect of S‐adenosyl‐L‐methionine (SAMe) on bromobenzene (BB)‐ or D‐galactosamine (GalN)‐induced damage to isolated rat hepatocytes and its effect on cellular glutathione (GSH) levels were investigated. SAMe at concentrations of 0.5 to 3.0 mmol/L significantly reduced lactate dehydrogenase leakage from cells exposed to 1.6 mmol/L BB (P < .05 to .001) during 2 hours' incubation.

J Prieto, J R Yuste, O Beloqui, M P Civeira, J I Riezu, B Aguirre, B Sangro – 1 February 1996 – Antiphospholipid antibodies are a type of autoantibodies that have been implicated in the occurrence of thrombocytopenia and thrombotic events and have been described in autoimmune disorders and diverse viral diseases. In this study anticardiolipin antibodies (immunoglobulin G [IgG] isotype) were determined in serum from 100 patients with chronic hepatitis C and 52 healthy controls.

S Zeuzem, J M Schmidt, J Lee, B Ruster, W K Roth – 1 February 1996 – In about 30% to 40% of patients with chronic hepatitis C, treatment with recombinant interferon alfa (r‐IFNα) causes a decrease of serum aminotransferases and hepatitis C virus (HCV) RNA. The antiviral mechanism of interferon alfa (IFNα) in vivo is unknown. From serial measurements of serum HCV‐RNA concentrations following IFNα induced perturbation of the balance between virus production and clearance, we obtained kinetic information on the pretreatment steady‐state of HCV.

P J O'Connor, K W Southern, I M Bowler, H C Irving, P J Robinson, J M Littlewood – 1 February 1996 – This was a prospective open study that examined the quantitative and qualitative analysis of hepatobiliary scintigraphy (DISIDA) in detecting liver involvement in cystic fibrosis (CF).

O Farges, F Saliba, H Farhamant, D Samuel, A Bismuth, M Reynes, H Bismuth – 1 February 1996 – A retrospective analysis was undertaken to determine if the incidence, timing, and severity of acute and chronic rejection were influenced by the primary disease necessitating transplantation. Of the 875 liver transplantations performed between 1984 and 1992, 768 were primary transplantations and 107 were retransplantations.

1 January 1996

Victor L. Scott – 1 January 1996

Nancy Rolando, Jeremy J. Wade, Arie Stangou, Alexander E. S. Gimson, Julia Wendon, John Philpott‐Howard, Mark W. Casewell, Roger Williams – 1 January 1996 – The efficacy of prophylactic parenteral antibacterials, with or without selective decontamination of the digestive tract, was compared in patients with acute liver failure (ALF) or severe acetaminophen hepatotoxicity.

1 January 1996