J Villeneuve, M Dagenais, P Huet, A Roy, R Lapointe, D Marleau – 1 January 1996 – In cirrhosis, capillarization of sinusoids could result in impaired exchanges between the hepatocytes and the blood perfusing the liver and contribute to liver failure irrespective of the metabolic capacity of the liver. To characterize anomalies of the hepatic microcirculation, we used the multiple‐indicator dilution approach in isolated perfused livers obtained from patients with cirrhosis at the time of transplantation, and from organ donors with normal or near‐normal livers or hepatic steatosis.

Michael F. Sorrell, Byrs W. Shaw – 1 January 1996

1 January 1996

Israel Penn – 1 January 1996 – De novo cancers occurred after transplantation in 8,008 organ allograft recipients, who developed 8,531 different types of malignancy. Three hundred twenty‐four liver recipients developed 329 cancers. There were striking differences in the patterns of neoplasms observed when these were compared with 7,200 tumors that occurred in renal allograft recipients.

W. Kenneth Washburn, Lynt B. Johnson, W. David Lewis, Roger L. Jenkins – 1 January 1996 – Patients with adult polycystic liver disease and massive cystic replacement of the liver may present with severe debilitation and impairment of functional performance or, rarely, with signs of portal hypertension or hepatic dysfunction. In those patients incapacitated by severe hepatomegaly secondary to massive cystic replacement with predominantly small cysts (2 cm) without areas of parenchymal sparing, liver transplantation is a therapeutic option.

S H Uchman, R Cesar – 1 January 1996

P Nagy, H C Bisgaard, E Santoni‐Rugiu, S S Thorgeirsson – 1 January 1996 – Expression of several growth factors is elevated in rat liver, after induction of oval cell proliferation by chemical carcinogens. However, the exact roles played by individual factors are not defined. We infused and examined the effects of epidermal growth factor (EGF) and hepatocyte growth factor (HGF) on the proliferation of ductal and periductal cells after their activation with 2‐acetylaminofluorene (2‐ AAF).

G R Locke, T M Therneau, J Ludwig, E R Dickson, K D Lindor – 1 January 1996 – Histological staging is used for stratification and assessment of treatment efficacy in therapeutic trials for primary biliary cirrhosis (PBC). Knowledge of the rate of progression of the histological changes would be helpful in the design (duration) and conduct of clinical trials. The histological stages were recorded for liver biopsies performed annually on 222 patients during a randomized, placebo‐ controlled clinical trial in which therapy with D‐penicillamine (DPCA) was shown to be ineffective.

E Albano, P Clot, M Morimoto, A Tomasi, M Ingelman‐Sundberg, S W French – 1 January 1996 – We have previously shown that the treatment with diallyl sulfide (DAS) and phenylethyl isothiocyanate (PIC) of rats receiving ethanol in the alcohol tube‐feeding model effectively suppressed the induction of cytochrome P4502E1 (CYP2E1) by ethanol. Here we report that rat treatment with DAS and PIC significantly decreased the trapping of hydroxyethyl free radicals in liver microsomes incubated in vitro with ethanol.

R T Mathie, V Ralevic, K P Moore, G Burnstock – 1 January 1996 – The contribution of nitric oxide to mesenteric arterial vasodilator responses was investigated in the isolated perfused mesenteric arterial bed of cirrhotic rats (carbon tetrachloride/phenobarbitone; n = 6). Age‐ matched (n = 9) and phenobarbitone‐treated rats (n = 9) served as controls.