J T Deng, M F Hoylaerts, E J Nouwen, M E De Broe, V O Van Hoof – 1 March 1996 – Membrane‐bound liver alkaline phosphatase (Mem‐LiALP, EC 3.1.3.1) is a high‐molecular‐mass liver alkaline phosphatase (ALP) present in metastatic, infiltrative and cholestatic liver disease. Shedding of hepatocyte plasma membrane fragments (LiPMF) is thought to be responsible for the appearance of Mem‐LiALP in the circulation. Several other membrane‐bound enzymes, such as γ‐glutamyltransferase (γ‐GT), leucine aminopeptidase (LAP), and 5′‐nucleotidase (5′‐Nu) are present in the membrane of the shedded LiPMF.

A M Gressner, B Polzar, B Lahme, H Mannherz – 1 March 1996 – The induction of apoptosis of rat liver parenchymal cells (PC) by transforming growth factor β (TGF‐β)‐expressing transforming fat‐storing cells (FSC), i.e., myofibroblasts (MFB), was studied under culture conditions and compared with the apoptotic effect of human recombinant TGF‐β1. MFB were obtained by subculture of FSC.

F Wong, A Logan, L Blendis – 1 March 1996 – Insulin has been shown to be vasodilatory and antinatriuretic and to stimulate sympathetic nervous activity independent of hypoglycemia in healthy normal subjects. It is hypothesized that hyperinsulinemia, which is commonly observed in cirrhosis, may in part be responsible for the systemic vasodilatation, sympathetic activation, and sodium retention in these patients.

K D Lindor, J Hoofnagle, W C Maddrey, I E Mackay, E R Dickson – 1 March 1996

S Moteki, P S Leung, E R Dickson, D H Van Thiel, C Galperin, T Buch, D Alarcon‐Segovia, D Kershenobich, K Kawano, R L Coppel, S Matuda, M E Gershwin – 1 March 1996 – Five different target mitochondrial autoantigens recognized by sera from patients with primary biliary cirrhosis (PBC) have been identified as subunits of the following 2‐oxo acid dehydrogenase complexes: the pyruvate dehydrogenase complex (PDC), the branched chain 2‐oxo acid dehydrogenase complex (BCOADC), and the 2‐oxoglutarate dehydrogenase complex (OGDC).

Y Tameda, M Hamada, K Takase, T Nakano, Y Kosaka – 1 March 1996 – The cause of fulminant hepatic failure is reported to be unknown in more than half the cases in Japan. We recently reviewed 23 cases of fulminant hepatic failure that had been treated at our hospital. The cause of disease had been regarded as unknown before this study. It was found that seven of these patients had been under ecarazine hydrochloride therapy when they developed fulminant hepatic failure.

H Lin, M C Yang, M Hou, S Li, Y Huang, P Yu, Y Tsai, S Lee – 1 March 1996 – The hemodynamic effects of long‐term administration of octreotide in portal hypertension has not been established. In addition, whether long‐term octreotide treatment prevents the development of portosystemic shunts has not yet been evaluated. Hence, the current study was undertaken to evaluate the effects of long‐term administration of octreotide in rats with portal vein stenosis.

G D Schapiro, L S Friedman – 1 March 1996

Jean C. Emond, Scott D. Kelley, Thomas G. Heffron, Tomonori Nakagawa, John P. Roberts, Robert C. Lim – 1 March 1996 – Total vascular exclusion (TVE) of the liver is accomplished by complete occlusion of inflow and outflow of the liver during hepatectomy. It affords the opportunity for bloodless, anatomically precise parenchymal transection but has not been widely used in this country. TVE should make it possible to treat large or unfavorably located lesions safely. To evaluate the benefit of this modality, we have examined the results of TVE in 49 major resections.

Christine M. Hunt, Julie S. Tart, Elaine Dowdy, Barbara Philips Bute, Diane M. Williams, Pierre‐Alain Clavien – 1 March 1996 – Employment, functional status, health status, and prevalence of anxiety and depression were assessed in patients who had undergone orthotopic liver transplantation at Duke University from 1984 to 1993 to identify social and economic factors that might influence return to work after liver transplantation. Patients were asked to complete mailed questionnaires. A transplant nurse coordinator assigned patients a Karnofsky score, unaware of the questionnaire responses.