Prospective study comparing the efficacy of prophylactic parenteral antimicrobials, with or without enteral decontamination, in patients with acute liver failure

Nancy Rolando, Jeremy J. Wade, Arie Stangou, Alexander E. S. Gimson, Julia Wendon, John Philpott‐Howard, Mark W. Casewell, Roger Williams – 1 January 1996 – The efficacy of prophylactic parenteral antibacterials, with or without selective decontamination of the digestive tract, was compared in patients with acute liver failure (ALF) or severe acetaminophen hepatotoxicity.

Blunted natriuretic response to low‐dose brain natriuretic peptide infusion in nonazotemic cirrhotic patients with ascites and avid sodium retention

Giorgio La Villa, Donato Riccardi, Chiara Lazzeri, Vincenzo Casini Raggi, Antonio Dello Sbarba, Cristina Tosti Guerra, Caterina Fronzaroli, Marco Foschi, Giacomo Laffi, Paolo Gentilini – 1 December 1995 – Patients with cirrhosis and ascites have high plasma levels of atrial (ANP) and brain (BNP) natriuretic peptides, two cardiac hormones released by the atria and ventricles, respectively.

Gene expression of N‐acetylglucosaminyltransferases III and V: A possible implication for liver regeneration

Elji Miyoshi, Yoshito Ihara, Atsushi Nishikawa, Hiroyuki Saito, Naofumi Uozumi, Norio Hayashi, Hideyuki Fusamoto, Takenobu Kamada, Naoyuki Taniguchi – 1 December 1995 – N‐acetylglucosaminyltransferases III and V (GnT‐III and ‐V) are key enzymes in the synthesis of the branches of asparagine‐linked oligosaccharides. Although their messenger RNAs (mRNAs) are expressed in various rat tissues, they are not detected in normal rat liver. Expression of the GnT‐III and ‐V mRNAs, however, increased in regenerating liver after two‐thirds partial hepatectomy compared with sham‐operated rats.

Deoxycholic acid influences cholesterol solubilization and microcrystal nucleation time in gallbladder bile

S. Hyder Hussaini, Stephen P. Pereira, Gerard M. Murphy, R. Hermon Dowling – 1 December 1995 – Little is known about the effects of biliary deoxycholic acid on the partitioning of biliary cholesterol between vesicles and micelles and on the rate of nucleation of cholesterol microcrystals, key steps in gallstone formation. Therefore, 43 samples of fresh gallbladder bile were obtained from a heterogeneous group of patients with and without stones.

The integrity of the cholecystokinin receptor gene in gallbladder disease and obesity

Gerardo Nardone, Irene A. Ferber, Laurence J. Miller – 1 December 1995 – Cholesterol gallstone disease and obesity are common and often associated disorders that could be affected by dysfunction of the receptor for cholecystokinin (CCK). Extending earlier studies that identified a defect at the level of receptor‐G protein coupling in cholesterol gallstone disease, we characterized the primary structure of the gallbladder CCK receptor in patients undergoing a cholecystectomy.

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