Selective portal vein embolization with absolute ethanol induces hepatic hypertrophy and makes more extensive hepatectomy possible

K Ogasawara, J Uchino, Y Une, Y Fujioka – 1 February 1996 – Portal vein embolization has been used recently to decrease the amount of the liver to be resected and to enhance the function of the remaining hypertrophied lobes. We have observed a strong contact destructivity of absolute ethanol and used it for portal vein embolization. The present study was performed to produce hepatic hypertrophy and to show histopathologic changes that follow ethanol embolization of rat liver.

Noncholesterol sterols in bile and stones of patients with cholesterol and pigment stones

T E Miettinen, Y A Kesaniemi, H Gylling, H Jarvinen, E Silvennoinen, T A Miettinen – 1 February 1996 – Human bile and cholesterol gallstones contain sterols including methylated (lanosterol and other dimethyl and monomethyl sterols), and demethylated cholesterol precursor sterols (Δ 8‐lathosterol, lathosterol, and desmosterol), plant sterols (campesterol and sitosterol), and cholestanol.

Cirrhosis and muscle cramps: Evidence of a causal relationship

P Angeli, G Albino, P Carraro, M D Pria, C Merkel, L Caregaro, E De Bei, A Bortoluzzi, M Plebani, A Gatta – 1 February 1996 – The aim of the study was to define the features, prevalence, and pathophysiology of therapy for muscle cramps in cirrhotic patients. The first protocol study included 294 cirrhotic patients and 194 age‐ and sex‐matched controls. Controls were defined as inpatients or outpatients without any clinical and laboratory evidence of liver disease. Features and prevalence of muscle cramps were defined on the basis of a standard questionnaire.

High incidence of ADH2*1/ALDH2*1 genes among Japanese alcohol dependents and patients with alcoholic liver disease

F Tanaka, Y Shiratori, O Yokosuka, F Imazeki, Y Tsukada, M Omata – 1 February 1996 – In an attempt to clarify the genetic factors in alcoholism among the Japanese, polymorphism of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes has been investigated.

Tumor necrosis factor α gene expression and the response to interferon in chronic hepatitis C

E Larrea, N Garcia, C Qian, M P Civeira, J Prieto – 1 February 1996 – Tumor necrosis factor α (TNF‐α) is a cytokine with pleiotropic properties that is induced in a variety of pathological situations including viral infections. In this work, we analyzed the expression of TNF‐α gene in patients with chronic hepatitis C. Serum TNF‐α levels were found to be elevated in all chronic hepatitis C patients including those cases presenting sustained biochemical remission of the disease after interferon therapy.

The antiandrogen cyproterone acetate induces synthesis of transforming growth factor β1 in the parenchymal cells of the liver accompanied by an enhanced sensitivity to undergo apoptosis and necrosis without inflammation

F Oberhammer, P Nagy, R Tiefenbacher, G Froschl, B Bouzahzah, S S Thorgeirsson, B Carr – 1 February 1996 – Recently, cases of liver damage and liver tumors have been reported after treatment of prostate cancer patients with the antiandrogen cyproterone acetate (CPA). In rat liver, CPA initiates a wave of DNA synthesis that is accompanied by apoptosis. In apoptotic hepatocytes, a latent form of transforming growth factor β1 (TGF‐β1) is detectable by immunohistochemistry.

Role of adhesion molecules in the development of massive hepatic necrosis in rats

S Mochida, A Ohno, M Arai, T Tamatani, M Miyasaka, K Fujiwara – 1 February 1996 – Massive hepatic necrosis develops after endotoxin administration in rats pretreated with heat‐killed Propionibacterium acnes as a result of microcirculatory disturbance caused by endothelial cell destruction by activated macrophages in the hepatic sinusoids.

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