Luba Dumenco, Delphine Oguey, Justina Wu, Norma Messier, Nelson Fausto – 1 October 1995 – The p53 gene is frequently mutated in human tumors; in hepatocellular carcinomas, there is a high frequency of a specific mutation at codon 249 in regions with significant aflatoxin exposure. To assess the role of this p53 mutation in the development of hepatocellular carcinoma, a mutant murine p53 gene, p53ser246, which corresponds to human codon 249, was transfected into a differentiated, nontransformed hepatocyte cell line AML12.

Gregorio Varela‐Moreiras, Elena Alonso‐Aperte, Mireia Rubio, Marta Gasso, Ramón Deulofeu, Luis Alvarez, Juan Caballería, Juan Rodés, José M. Mato – 1 October 1995 – Carbon tetrachloride (CCl4) administration to rats produces hepatic cirrhosis and supplementation with S‐adenosylmethionine (SAM) can partially prevent CCl4‐induced liver injury. These effects are thought to be caused by oxidative stress and the subsequent formation of free radicals, but the mechanism whereby this occurs and the accurate nature of the mechanisms by which SAM exerts its protective action are not well understood.

Hari S. Conjeevaram, James E. Everhart, Jay H. Hoofnagle – 1 October 1995

T. Jake Liang – 1 October 1995

John M. Cullen, Caroline David, Jia‐Gang Wang, Paul Becherer, Stanley M. Lemon – 1 October 1995 – Hepatitis delta virus (HDV) encodes only a single protein, the hepatitis delta antigen (HDAg), which is expressed as two molecular forms (large and small) with different functions in viral replication. Compared with small antigen, large antigen has a 19 residue carboxyl terminal extension.

Yasushi Shiratori, Shuichiro Shiina, Masatoshi Imamura, Naoya Kato, Fumihiko Kanai, Takahito Okudaira, Takuma Teratani, Gohichi Tohgo, Nobuo Toda, Makoto Ohashi, Keiji Ogura, Yasuro Niwa, Takao Kawabe, Masao Omata – 1 October 1995 – Characteristics of 205 consecutive patients with hepatocellular carcinoma (HCC) admitted during 1990 to 1993 have been analyzed from the standpoint of hepatitis viral infection in Japan.

Reem Ghalib, Todd Howard, Jeffrey Lowell, Phyllis Huettner, Alison Whelan, Sharlene Teefey, Marion Peters, Heather White – 1 October 1995

Desmond J. Farrell, Julie E. Hines, Andrew F. Walls, Peter J. Kelly, Mark K. Bennett, Alastair D. Burt – 1 October 1995 – Mast cells are known to be present in human liver but their distribution and density in normal livers and in chronic liver diseases have not previously been examined. In this study, we quantified mast cell numbers and examined their distribution in percutaneous biopsy specimens from normal livers (n = 8) and in two chronic progressive liver diseases: primary biliary cirrhosis (PBC) (n = 40) and alcoholic liver disease (n = 33).

Sarah Shefer, Betsy T. Kren, Gerald Salen, Clifford J. Steer, Lien B. Nguyen, Thomas Chen, G. Stephen Tint, Ashok K. Batta – 1 October 1995 – We examined the effects of feeding deoxycholic acid (1% and 0.4% of diet), alone and in combination with ursodeoxycholic acid, on serum and biliary bile acid concentrations, hepatic morphology, and the activities and steady‐state messenger RNA (mRNA) levels of HMG‐CoA reductase and cholesterol 7α‐hydroxylase in the rat.

Yasuhiro Shimizu, Hiroshi Suzuki, Yuji Nimura, Shigemi Onoue, Masato Nagino, Masashi Tanaka, Takayuki Ozawa – 1 October 1995 – We explored the molecular basis of mitochondrial energy production during rat liver regeneration after portal vein ligation. Ligation of the left branch of the portal vein induces an increase in the weight of the nonligated lobe, counterbalancing the reduced weight of the ligated lobe. Using this model, we investigated changes in mitochondrial DNA‐binding proteins, mitochondrial DNA, and mitochondrial messenger RNA (mRNA) in rat hepatocytes of the nonligated lobes.