Proliferation, apoptosis, and induction of hepatic transcription factors are characteristics of the early response of biliary epithelial (oval) cells to chemical carcinogens

H C Bisgaard, P Nagy, E Santoni‐Rugiu, S S Thorgeirsson – 1 January 1996 – In this study, we used [3H]thymidine labeling of newly synthesized DNA to examine the earliest effects of 2‐acetylaminofluorene (2‐AAF) on the mitotic activation of cells in the adult rat liver, and in situ hybridization analysis to study the expression of three transcription factors (HNF1 beta, HNF3 γ, and HNF4), and two of the genes (α‐fetoprotein [AFP] and albumin) regulated by these factors.

Direct measurement of hepatic indocyanine green clearance with near‐infrared spectroscopy: Separate evaluation of uptake and removal

H Shinohara, A Tanaka, T Kitai, N Yanabu, T Inomoto, S Satoh, E Hatano, Y Yamaoka, K Hirao – 1 January 1996 – We continuously measured hepatic absorbance of indocyanine green (ICG) using near‐infrared (NIR) spectroscopy after intravenous bolus injection in rabbits. Hepatic ICG concentration was obtained by subtracting out the absorbance of hemoglobin and other pigments within the liver.

Hepatitis C dilemma?

Nancy L. Ascher, Cyrille Féray, Didier Samuel, Michèle Gigou, Valérie Paradis, Marie Françoise David, Catherine Lemonnier – 1 January 1996 – The aim of this open trial was to assess the efficacy and the safety of interferon (IFN) alfa therapy in liver transplant recipients with chronic active hepatitis caused by hepatitis C virus. In July 1991, among 447 liver recipients regularly observed at our institution, 46 had developed HCV‐related chronic active hepatitis defined by piece meal necrosis.

Prospective study comparing the efficacy of prophylactic parenteral antimicrobials, with or without enteral decontamination, in patients with acute liver failure

Nancy Rolando, Jeremy J. Wade, Arie Stangou, Alexander E. S. Gimson, Julia Wendon, John Philpott‐Howard, Mark W. Casewell, Roger Williams – 1 January 1996 – The efficacy of prophylactic parenteral antibacterials, with or without selective decontamination of the digestive tract, was compared in patients with acute liver failure (ALF) or severe acetaminophen hepatotoxicity.

Blunted natriuretic response to low‐dose brain natriuretic peptide infusion in nonazotemic cirrhotic patients with ascites and avid sodium retention

Giorgio La Villa, Donato Riccardi, Chiara Lazzeri, Vincenzo Casini Raggi, Antonio Dello Sbarba, Cristina Tosti Guerra, Caterina Fronzaroli, Marco Foschi, Giacomo Laffi, Paolo Gentilini – 1 December 1995 – Patients with cirrhosis and ascites have high plasma levels of atrial (ANP) and brain (BNP) natriuretic peptides, two cardiac hormones released by the atria and ventricles, respectively.

Gene expression of N‐acetylglucosaminyltransferases III and V: A possible implication for liver regeneration

Elji Miyoshi, Yoshito Ihara, Atsushi Nishikawa, Hiroyuki Saito, Naofumi Uozumi, Norio Hayashi, Hideyuki Fusamoto, Takenobu Kamada, Naoyuki Taniguchi – 1 December 1995 – N‐acetylglucosaminyltransferases III and V (GnT‐III and ‐V) are key enzymes in the synthesis of the branches of asparagine‐linked oligosaccharides. Although their messenger RNAs (mRNAs) are expressed in various rat tissues, they are not detected in normal rat liver. Expression of the GnT‐III and ‐V mRNAs, however, increased in regenerating liver after two‐thirds partial hepatectomy compared with sham‐operated rats.

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