Cesar Roncero, Isabel Fabregat, Manuel Benito – 1 December 1995 – Fetal rat hepatocytes incubated in the absence of hormonal signals, or under proliferative (presence of epidermal growth factor [EGF]) or differentiative (presence of dexamethasone) culture conditions, showed responsiveness to interleukin‐6 (IL‐6). Northern blotting analysis for some typical acute phase genes such as haptoglobin and other proteins not previously identified as acute‐phase reactants, such as α‐fetoprotein, β2‐microglobulin, and fibronectin, showed a positive modulation by IL‐6, in a dose‐dependent manner.

Ikuo Shoji, Tetsuro Suzuki, Shinya Chieda, Mitsuru Sato, Takashi Harada, Tsutomu Chiba, Yoshiharu Matsuura, Tatsuo Miyamura – 1 December 1995 – The serine proteinase of hepatitis C virus (HCV) nonstructural protein NS3 was efficiently expressed in an active form as a fused protein with oligohistidine in Escherichia coli. The recombinant fusion protein was purified to near homogeneity by affinity chromatography on a metal chelation column. Trans‐cleavage activity of this protein was investigated by using the substrate NS5 protein expressed in insect cells.

Petra E. Steindl, Jeanne Gottstein, Andres T. Blei – 1 December 1995 – A recent study suggested that female rats are less affected by a portacaval anastomosis (PCA) than their male counterparts, as measured by body weight and changes in locomotor activity. In this study, we evaluated the entrainment of locomotor activity to the light/dark (LD) cycle, a consistent abnormality in the portacaval shunted rat. The degree of entrainment was measured in male and female rats before and after PCA or sham operation. All four groups of animals showed strong entrainment to an LD cycle before surgery.

Koichiro Yamakado, Kan Takeda, Yoshiya Nishide, Jugangu Jin, Kaname Matsumura, Atsuhiro Nakatsuka, Tadanori Hirano, Noriyuki Kato, Tsuyoshi Nakagawa – 1 December 1995 – Portal vein embolization (PVE) is expected to have an adjuvant effect on the treatment of human liver tumors with transcatheter hepatic arterial embolization (TAE). In this experimental study, PVE was tried using two kinds of embolic materials, steel coils (coils) and absolute ethanol (ethanol). The aim of this article is to compare the effectiveness between the two methods.

Raymond S. Koff – 1 December 1995

Daniel Cherqui, Alain Rahmouni, Frédéric Charlotte, Hatem Boulahdour, Michel Meignan, Pierre‐Louis Fagniez, Elie‐Serge Zafrani, Didier Mathieu, Daniel Dhumeaux, Jean‐Michel Métreau – 1 December 1995 – Preoperative distinction between focal nodular hyperplasia (FNH) that should be managed conservatively and hepatocellular adenoma (HA) that should be resected remains difficult. The result is controversial management of these patients.

Hideya Noguchi, Kenji Hirai, Yoshinori Aoki, Kenji Sakata, Kyuichi Tanikawa – 1 December 1995 – We performed a partial splenic arterial embolization in 22 patients with cirrhosis associated with thrombocy‐topenia and then evaluated the changes in platelet kinetics after undergoing the procedure using 111In‐tropolone–labeled platelets. The controls consisted of eight chronic hepatitis patients who showed a normal platelet count and normal spleen size. The mean splenic infarction ratio after the procedure was 54.9%.

Naokatu Arakaki, Shuichi Kawakami, Osamu Nakamura, Tomokazu Ohnishi, Hiroomi Miyazaki, Takehisa Ishii, Hirohito Tsubouchi, Yasushi Daikuhara – 1 December 1995 – Human hepatocyte growth factor (hHGF), which is now known to be the same protein as the scatter factor and the tumor cytotoxic factor, is a heterodimeric protein with one heavy chain and one light chain linked together by a disulfide bond, and is thought to be involved in liver regeneration.

Gerald Y. Minuk, Tony Gauthier, Xin K. Zhang, Gu Qi Wang, Norman M. Pettigrew, Frank J. Burczynski – 1 December 1995 – To determine whether the inhibitory effects of ethanol on hepatic regeneration could be prevented by ciprofloxacin, a fluroquinolone antibiotic with gammaaminobutyric acid (GABAA), receptor antagonist properties, adult, male Sprague‐Dawley rats (n = 6‐8/group) received intraperitoneal injections of saline, putrescine (a hepatic growth promotor, 50 mg/kg), or ciprofloxacin (100 mg/kg), followed 1 hour later by gastric gavage with saline or ethanol (5 g/kg).

Ernst Petzinger, Lutz Nickau, Jurgen A. Horz, Siegfried Schulz, Gunther Wess, Alfons Enhsen, Eugen Falk, Karl‐Heinz Baringhaus, Heiner Glombik, Axel Hoffmann, Stefan Müllner, Georg Neckermann, Werner Kramer – 1 December 1995 – To obtain prodrugs with affinity to liver parenchymal cells, the hepatic 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase inhibitors HR 780 and lovastatin (syn. mevinolin) were conjugated with the bile acids cholic acid, taurocholic acid, and glycocholic acid.