Anna S. F. Lok – 1 October 1995 – Objective: To estimate the cost‐effectiveness of interferon‐α2B for the treatment of patients with chronic hepatitis B infection who are positive for hepatitis B e antigen (HBeAg).
1 October 1995
1 October 1995
Masayoshi Yamauchi, Yoshihiko Maezawa, Yuji Mizuhara, Mitsuru Ohata, Junichi Hirakawa, Hisato Nakajima, Gotaro Toda – 1 October 1995 – Alcohol dehydrogenase (ADH), aldehyde dehydrognase (ALDH), and P450IIE1 are the primary enzymes that catalyze the conversion of ethanol to acetaldehyde and then to acetate. Genetic polymorphisms have been reported in ADH2, ADH3, ALDH2, and the 5′‐flanking region of P450IIEI.
Francis V. Chisari – 1 October 1995
Carl L. Berg – 1 October 1995 – Crigler‐Najjar (CN) disease is classified into two subtypes, type I and II. The molecular basis for the difference between these types is not well understood.
Michael L. Schilsky – 1 October 1995 – The process of hepatobiliary copper (Cu) secretion is still poorly understood Cu secretion as a complex with glutathione and transport via a lysosomal pathway have been proposed. The recent cloning and sequencing of the gene for Wilson disease indicates that Cu transport in liver cells may be mediated by a Cu transporting Ptype ATPase. Biochemical evidence for ATP‐dependent Cu transport in mammalian systems, however, has not been reported so far.
John F. Renz, Chris L. Mudge, Melvin B. Heyman, Steve Tomlanovich, Ralph P. Kingsford, Barbara J. Moore, John D. Snyder, Hilary A. Perr, Amie L. Paschal, John P. Roberts, Nancy L. Ascher, Jean C. Emond – 1 October 1995 – The purpose of this investigation was to assess the applicability of living‐related liver transplantation in an established regional transplant program by determining the frequency of acceptable living donors from an unselected population of pediatric transplant candidates and identify specific factors limiting application of this technique.