Notices
1 November 1994
Internal biliary drainage, unlike external drainage, does not suppress the regeneration of cholestatic rat liver after partial hepatectomy
Hideaki Suzuki, Shinsuke Iyomasa, Yuji Nimura, Shonen Yoshida – 1 November 1994 – We previously showed that hepatic cells proliferate in obstructive jaundice alone without partial hepatectomy and found that external biliary drainage for obstructive jaundice markedly suppresses liver regeneration after partial hepatectomy. In this study, we produced a model system for internal biliary drainage in which bile was drained into the stomach of rat fed a liquid diet.
Alteration in growth regulation of hepatocytes in primary culture obtained from cirrhotic rat: Poor response to transforming growth factor‐β1 and interferons
Shinichi Kiso, Sumio Kawata, Shinji Tamura, Nobuyuki Ito, Kenji Takaishi, Yasuhiro Shirai, Hirofumi Tsushima, Yuji Matsuzawa – 1 November 1994 – Cell growth appears to be controlled by positive and negative cell growth regulation. Little is known about the growth regulation of hepatocytes in the cirrhotic liver. Clarifying the responses of hepatocytes obtained from cirrhotic liver to various growth factors and growth inhibitory factors might aid understanding of alterations in growth regulation of the hepatocytes in the cirrhotic liver.
Evaluation of vascular tone in portacaval shunts comparing the index of contractility and resistance in cats
Andrés C. Inglés, Dallas J. Legare, W. Wayne Lautt – 1 November 1994 – A model of prehepatic chronic portal hypertension in cats was used to determine portacaval shunt responses to infused norepinephrine and to possible transmitter overflow into portal blood from nerves supplying the gut. Responses are compared using a new index of contractility. Four weeks after application of a slowly constricting occluder, the portal vein was completely occluded and acute experiments were carried out under pentobarbital anesthesia.
Degree of diversity of hepatitis C virus quasispecies and progression of liver disease
Masao Honda, Shuichi Kaneko, Akito Sakai, Masashi Unoura, Seishi Murakami, Kenichi Kobayashi – 1 November 1994 – We examined the quasispecies of the hepatitis C virus genome in 28 patients with liver disease of varying severity.
Superinfection of chimpanzees carrying hepatitis C virus of genotype II/1b with that of genotype III/2a or I/1a
Hiroaki Okamoto, Shunji Mishiro, Hajime Tokita, Fumio Tsuda, Yuzo Miyakawa, Makoto Mayumi – 1 November 1994 – Three chimpanzees persistently infected with hepatitis C virus of genotype II/1b were challenged with hepatitis C virus of genotype III/2a and 6 wk later with hepatitis C virus of genotype I/1a. They were tested for titers of total and genotype‐specific hepatitis C virus RNA, as well as for serum transaminase levels, until 52 wk after the first challenge.
Inherited liver disease: Clinical teaching project. Unit 8, American Gastroenterological Association. By C.A. Riely, S.R. Vera, M.I. Burrell and R.S. Koff. Timonium, MD: Milner‐Fenwick, 1993. $125
Charles M. Noyer, Howard J. Worman – 1 November 1994
Tumor vaccination against hepatoma: How does it work?
Shuichi Hanada, Takaji Wakita, Hiroshi Takahashi – 1 November 1994 – Fusion of BERH‐2 rat hepatocellular carcinoma cells with activated B cells produced hybrid cells that lost their tumorigenicity and became immunogenic. Syngeneic rats injected with BERH‐2‐B hybrid cells became resistant to challenge with parental BERH‐2 cells, and rats with established BERH‐2 hepatomas were cured by subsequent injection of BERH‐2‐B cells. Both CD4 and CD8+ cells were essential for the induction of protective immunity; however, only CD8+ cells were required for the eradication of BERH‐2 tumors.