Hepatic preneoplasia in hepatitis B virus transgenic mice
Iljia Toshkov, Francis V. Chisari, Peter Bannasch – 1 November 1994 – Hepatocarcinogenesis in hepatitis B virus transgenic mice was studied by means of a correlative cytomorphological and cytochemical approach at different time points in animals from 1 to 34 mo old. HBsAg‐positive ground‐glass hepatocytes emerged throughout the liver parenchyma in nearly all transgenic mice during the first 4 mo after birth. The panlobular expression of HBsAg persisted until foci of altered hepatocytes appeared (6 to 9 mo of age).