Function and regulation of UDP‐glucuronosyltransferase genes in health and liver disease: Report of the seventh international workshop on glucuronidation, september 1993, Pitlochry, Scotland
Brian Burchell B.Sc. Ph.D. MCRPath., Michael W. H. Coughtrie, Peter L. M. Jansen – 1 December 1994
Propranolol plus isosorbide‐5‐mononitrate for portal hypertension in cirrhosis: Long‐term hemodynamic and renal effects
Rosa Maria Morillas, Ramon Planas, Eduard Cabré, Amparo Galán, Juan Carlos Quer, Faust Feu, Joan Carles García Pagán, Jaume Bosch, Miquel Angel Gassull – 1 December 1994 – The effect on kidney function, vasoactive systems and ascites outcome of long‐term treatment with propranolol plus isosorbide‐5‐mononitrate, a combined therapy proven more effective than propranolol alone in decreasing portal pressure in the cirrhotic patient, is unknown. Thirty cirrhotic patients who survived acute variceal bleeding and were treated with propranolol plus isosorbide‐5‐mononitrate were studied.
Daily determination of individual serum bile acids allows early detection of hepatic allograft dysfunction
Samy A. Azer, Geoffrey W. McCaughan, Neill H. Stacey – 1 December 1994 – Acute graft rejection is still a major cause of morbidity after orthotopic liver transplantation, and its diagnosis necessitates an invasive liver biopsy. Our aim has been to determine whether changes in individual serum bile acid levels after engraftment are sensitive, specific and reliable indicators of graft function and whether these changes can antedate other biochemical indicators of hepatic allograft rejection.
Hepatic and extrahepatic hepatitis C virus replication in relation to response to interferon therapy
Mohamed G. Saleh, Christopher J. Tibbs, John Koskinas, Leila M. M. B. Pereira, Adrian B. Bomford, Bernard C. Portmann, Ian G. McFarlane, Roger Williams – 1 December 1994 – Response to a 1‐yr course of interferon‐α2b was assessed in 18 patients with chronic hepatitis C virus infection in relation to clinical, biochemical and histological parameters and to the presence or absence of hepatitis C virus RNA and the presumed replicative form of the virus (negative‐strand hepatitis C virus RNA) in serum, liver and peripheral blood mononuclear cells.
Thyroid abnormalities in patients with chronic viral hepatitis
Miau‐Ju Huang – 1 December 1994
The physiological position of the liver in the circulation is not a major determinant of its functional capacity
Gerry T. M. Wagenaar, Robert A. F. M. Chamuleau, Martinus A. W. Maas, Kora De Bruin, Hans A. M. Korfage, Wouter H. Lamers – 1 December 1994 – The zonal patterns of gene expression in the liver of the rat are not affected by alteration of the afferent hepatic blood source. We investigated whether afferent hepatic blood source or flow rate affects the metabolic capacity of the liver. Using microsurgical techniques, we changed the afferent hepatic blood source to solely arterial blood, solely portal blood or solely caval blood.
Neonatal capsaicin treatment does not prevent splanchnic vasodilatation in portal‐hypertensive rats
Mercedes Fernández, Maria Casadevall, Rufina Schuligoi, Pilar Pizcueta, Julián Panés, M. Dolores Barrachina, Josef Donnerer, Josep M. Piqué, Juan V. Esplugues, Jaume Bosch M.D., Juan Rodés, Peter Holzer – 1 December 1994 – It has been suggested that the peripheral sensory neurons are involved in the splanchnic hemodynamic changes of portal hypertension. Therefore the influence of permanent ablation of sensory neurons by neonatal capsaicin pretreatment (50 mg/kg, subcutaneously) on the development of the hyperdynamic splanchnic circulation in portal‐hypertensive rats was studied.
Potential role of bile duct collaterals in the recovery of the biliary obstruction: Experimental study in rats using microcholangiography, histology, serology and magnetic resonance imaging
Yicheng Ni, Gregorius Lukito, Prof.Dr. Guy Marchal, Erwin Cresens, Jie Yu, Carine Petré, Albert L. Baert, Johan Fevery – 1 December 1994 – Obstructive cholestasis induced in animals at the level of the lobar and common bile ducts is known to be reversible with time. This study was conducted not only to test the hypothesis that formation of bile duct collaterals is responsible for the recovery of biliary obstruction but also to assess the potential of hepatobiliary agent‐enhanced magnetic resonance imaging for visualizing cholestasis.