Akihiro Tamori, Shuhel Nishiguchi, Tetsuo Kuroki, Shuichi Seki, Kenzo Kobayashi, Hiroaki Kinoshita, Shuzo Otani – 1 November 1994 – To evaluate the correlation between the polyamine metabolism and the degree of malignancy in hepatocellular carcinoma, we measured ornithine decarboxylase activity and polyamine concentrations in neoplastic tissue and adjacent noncancerous tissue from resected specimens of liver from 30 patients.

Iljia Toshkov, Francis V. Chisari, Peter Bannasch – 1 November 1994 – Hepatocarcinogenesis in hepatitis B virus transgenic mice was studied by means of a correlative cytomorphological and cytochemical approach at different time points in animals from 1 to 34 mo old. HBsAg‐positive ground‐glass hepatocytes emerged throughout the liver parenchyma in nearly all transgenic mice during the first 4 mo after birth. The panlobular expression of HBsAg persisted until foci of altered hepatocytes appeared (6 to 9 mo of age).

Mark E. Peeples – 1 November 1994 – In a previous study, we have identified endonexin II (E‐II) on human liver plasma membranes as a specific, Ca‐dependent, small hepatitis B surface antigen (HBsAg)‐binding protein. In this article, we describe the spontaneous development of anti‐HBs antibodies in rabbits immunized with native or recombinant human liver E‐II and in chickens immunized with the F(ab′)2 fragment of rabbit anti‐human liver E‐II immunoglobulin G. Anti‐HBs activity was not observed in rabbits immunized with rat liver E‐II.

Roberto J. Groszmann – 1 November 1994

Walter H. Abelmann – 1 November 1994

Kathryn A. Quinn, Alice C. Cavanagh, Narelle C. Hillyard, Dorothy A. McKay, Halle Morton – 1 November 1994 – Early pregnancy factor is not only a product of dividing embryonic and neoplastic cells, as demonstrated previously, but also of normal proliferating cells. Eight hours after partial hepatectomy in rats, early pregnancy factor was detected in serum. It rose to a peak by 48 hr.

Simon D. Taylor‐Robinson, Janet Sargentoni, Rosemary J. Mallalieu, Jimmy D. Bell, David J. Bryant, Glyn A. Coutts, Marsha Y. Morgan – 1 November 1994 – Cerebral phosphorus‐31 magnetic resonance spectroscopy was undertaken in 33 patients with biopsyproven cirrhosis: 6 had no evidence of neuropsychiatric impairment on standard clinical, psychometric and electrophysiological testing; 8 had evidence of subclinical hepatic encephalopathy; and 19 were classified as having overt hepatic encephalopathy. The reference population comprised 15 healthy volunteers.

Cyrille Féray, Michelle Gigou, Didier Samuel, Valérie Paradis, Judith Wilber, Marie France David, Mickey Urdea, Michel Reynes, Christian Bréchot, Henri Bismuth – 1 November 1994 – Hepatitis C virus—induced liver disease is becoming a main indication for liver transplantation. Recurrence of hepatitis after transplantation has been reported, but its long‐term consequences are unknown.

Masahide Oshita, Yoshiyuki Takei, Sunao Kawano, Taizo Hijioka, Eiji Masuda, Moritaka Goto, Yoshiya Nishimura, Hirotaka Nagai, Sadaharu Iio, Shingo Tsuji, Hideyuki Fusamoto, Takenobu Kamada – 1 October 1994 – The purpose of this study was to clarify the role of endogenous nitric oxide in ethanol‐induced perturbation of microcirculation and hepatic injury in perfused rat liver. Infusion of ethanol into the portal vein at 25 and 100 mmol/L increased portal pressure, which is an indicator of hepatic vasoconstriction, in a concentration‐dependent fashion.

Makoto Hoshino, Tomihiro Hayakawa, Asamitsu Hirano, Yasutaka Kamiya, Takayuki Ohiwa, Akitaka Tanaka, Tomoyuki Kumai, Takanori Inagaki, Makoto Miyaji, Toshihiko Takeuchi – 1 October 1994 – We investigated bile flow and biliary excretion of bile acids in the Eisai hyperbilirubinemic rat, a Sprague‐Dawley mutant rat with conjugated hyperbilirubinemia, using both in vivo and in vitro models. In vivo bile flow was lower in Eisai hyperbilirubinemic rats than in the control rats before and after taurocholate was infused.