1 October 1994

Nieves Rodriguez‐Henche, Luis G. Guijarro, Alain Couvineau, Isabel Carrero, Eduardo Arilla, Marc Laburthe, Juan C. Prieto – 1 October 1994 – Liver proliferation appears to be dually regulated, in part by cyclic AMP levels. Here we studied the alterations in the stimulatory action of cholera toxin and other agents on the adenylyl cyclase system, as well as the status of Gs and Gi protein subunits during the liver proliferation that follows bile duct ligation in rats.

Rafael Bruck, Michael H. Nathanson, Han Roelofsen, James L. Boyer – 1 October 1994 – Both protein kinase C and cytosolic Ca2+ are involved in the regulation of exocytosis in a number of cell types. However, the relative importance of each of these for apical exocytosis in the hepatocyte is unknown. To investigate this, we studied the effects of protein kinase C and Ca2+ agonists on horseradish peroxidase excretion in the isolated perfused rat liver.

Stefan G. Hubscher, Ann Williams, Suzanne M. Davison, Lawrence S. Young, Gerald Niedobitek – 1 October 1994 – The Epstein‐Barr virus is associated with a broad spectrum of lymphoproliferative diseases in liver allograft recipients. To investigate the effects of primary infection in children following liver transplantation and the possible role of Epstein‐Barr virus in the pathogenesis of unexplained chronic hepatitis after transplantation, we used an in situ hybridization technique to detect small virus encoded nuclear RNAs in posttransplant specimens.

A. Guan Lim, Riadh P. Jazrawi, Hafez A. Ahmed, Joanne H. Levy, Massimo Zuin, Andrew C. Douds, J. Douglas, Tim C. Northfield – 1 October 1994 – Intercellular adhesion molecule—1, strongly expressed on the interlobular and proliferating bile ducts in primary biliary cirrhosis, is important in the migration and adhesion of inflammatory cells from the circulation to these structures. A soluble form has been found to be elevated in serum in primary biliary cirrhosis.

Marshall J. Orloff, Richard H. Bell, Mark S. Orloff, William G. M. Hardison, A. Gerson Greenburg – 1 October 1994 – A prospective randomized trial was conducted in unselected, consecutive patients with bleeding esophageal varices resulting from cirrhosis comparing (1) emergency portacaval shunt performed within 8 hr of initial contact (21 patients) with (2) emergency medical therapy (intravenous vasopressin and esophageal balloon tamponade) followed in 9 to 30 days by elective portacaval shunt in survivors (22 patients).

Patrice Beaudry, Antoine Hadengue, Jacques Callebert, Christophe Gaudin, Hany Soliman, Richard Moreau, Jean Marie Launay, Didier Lebrec – 1 October 1994 – Serotoninergic mechanisms are thought to play a role in portal hypertension. Because this biomine is metabolized by the liver, peripheral blood and plasma levels of 5‐hydroxytryptamine and 5‐hydroxyindole acetic acid (the main metabolite of 5‐hydroxytryptamine) were measured in 30 patients with cirrhosis.

Raymond S. Koff – 1 October 1994

William R. Brugge – 1 October 1994 – Background/Aims: Endoscopic ultrasonography is a promising procedure for the diagnosis of extrahepatic cholestasis. Accuracy for the diagnosis of choledocholithiasis by ultrasonography and computed tomography were prospectively compared with endoscopic ultrasonography in 62 consecutive patients.

J. Michael Henderson, Norman D. Grace – 1 October 1994