Luisa Schiaffonati, Lorenza Tacchini, Carmela Pappalardo – 1 October 1994 – Heat shock response in cultured cells has been studied extensively; however few data are available on heat shock response in an intact organ of a living animal. In this study we analyzed the kinetics of expression of the heat shock protein 70 gene family (heat shock protein 70, heat shock cognate protein 73 and glucose‐regulated protein 78) in the liver of the thermally stressed rat.

Olivier Le Moine, Arnaud Marchhant, François Durand, Brigitte Ickx, Olrvier Pradier, Jacques Belghiti, Daniel Abramowicz, Michel Gelin, Michel Goldman, Jacques Devière – 1 October 1994 – Experimental and clinical observations indicate that the liver allograft is less immunogenic than other organ transplants and can promote immune tolerance. Because interleukin‐10 recently emerged as a macrophage and T‐cell‐derived cytokine with potent immunosuppressive properties, we studied its production in 28 patients undergoing orthotopic liver transplantation.

Yoshikazu Murawaki, Yujiro Ikuta, Masahiko Koda, Hironaka Kawasaki – 1 October 1994 – To assess the clinical value of serum biochemical markers, the aminoterminal peptide of type III procollagen, type IV collagen 7S domain, the central triplehelix of type IV collagen and tissue inhibitor of metalloproteinases, as a marker of hepatic fibrosis, we measured these four serum markers in 132 patients with chronic viral liver disease and compared these serum markers with liver histological findings.

Judy Van De Water, M. Eric Gershwin – 1 October 1994 – Background/Aims: A strong association exists between ulcerative colitis and primary sclerosing cholangitis (PSC). Previously, the presence of a unique epitope shared by colon and biliary epithelial cells was shown by using the novel monoclonal antibody (MAb) 7E12H12 developed against a colonic epithelial protein. In the present study, the presence of circulating autoantibody in PSC against this peptide was examined.

Barry J. Potter, Jia‐Zhang Ni, Kathleen Wolfe, Decherd Stump, Paul D. Berk – 1 October 1994 – To determine whether phenobarbital affects hepatocellular bilirubin/sulfobromophthalein uptake mechanism, we administered it to male Sprague‐Dawley rats, body weight 175 ± 25 gm, at doses of 1 to 75 mg/kg body wt/day for 7 days. Control rats were given an equivalent volume of physiological saline solution.

Maria Giulia Battelli, Laura Buonamici, Andrea Bolognesi, Fiorenzo Stirpe – 1 October 1994 – A Ber‐H2/saporin immunotoxin, consisting of the single‐chain ribosome‐inactivating protein saporin‐S6 and the anti‐CD30 monoclonal antibody Ber‐H2, gave encouraging results in the treatment of refractory Hodgkin's disease but caused a transient hepatotoxicity. The accumulation of Ber‐H2/saporin conjugate and of its components by rat liver parenchymal and nonparenchymal cells was studied.

T. Jake Liang, M. Sawkat Anwer, Bruce R. Bacon, Henry C. Bodenheimer, James M. Crawford, Norman D. Grace, Sanjeev Gupta, Joel Lavine, Arun J. Sanyal – 1 October 1994 – One hundred patients underwent transjugular intrahepatic portosystemic shunt (TIPS) creation for variceal bleeding (n = 94), intractable ascites (n = 3), hepatorenal syndrome (n = 2), and preoperative portal decompression (n = 1). Shunts were completed in 96 patients.

Paolo Angeli, Wladimiro Jiménez, Vicente Arroyo, Harald S. Mackenzie, Ping L. Zhang, Joan Clária, Francisca Rivera, Barry M. Brenner, Joan Rodés – 1 October 1994 – The aim of this study was to assess the effect of HS‐142‐1, a recently discovered specific antagonist of endogenous natriuretic peptides, on systemic hemodynamics, renal function, and the renin‐aldosterone system in rats with cirrhosis and ascites. The study consisted of three protocols, each including 10 conscious control rats and 10 conscious rats with carbontetrachloride‐induced cirrhosis with ascites.

Raymond S. Koff, Kevin D. Mullen – 1 October 1994

María Cascales, Alberto Alvarez, Pilar Gascó, Lourdes Fernández‐Simón, Nuria Sanz, Lisardo Boscá – 1 October 1994 – Liver injury was induced by a single dose (60 mg/kg) of cocaine in male albino Swiss mice untreated or pretreated with phenobarbital (in drinking water 1 gm/L), for 5 days before cocaine administration. One parameter of liver injury, serum isocitrate dehydrogenase activity, showed sharp increases at 24 hr of cocaine treatment; we also noted decreased hepatic levels of ATP, GSH, cytochrome P‐450 and NADPH/NADP+ ratio and increases in malondialdehyde concentration.