Olivier Le Moine, Arnaud Marchhant, François Durand, Brigitte Ickx, Olrvier Pradier, Jacques Belghiti, Daniel Abramowicz, Michel Gelin, Michel Goldman, Jacques Devière – 1 October 1994 – Experimental and clinical observations indicate that the liver allograft is less immunogenic than other organ transplants and can promote immune tolerance. Because interleukin‐10 recently emerged as a macrophage and T‐cell‐derived cytokine with potent immunosuppressive properties, we studied its production in 28 patients undergoing orthotopic liver transplantation.

Luisa Schiaffonati, Lorenza Tacchini, Carmela Pappalardo – 1 October 1994 – Heat shock response in cultured cells has been studied extensively; however few data are available on heat shock response in an intact organ of a living animal. In this study we analyzed the kinetics of expression of the heat shock protein 70 gene family (heat shock protein 70, heat shock cognate protein 73 and glucose‐regulated protein 78) in the liver of the thermally stressed rat.

Akihiko Kimura, Ryoichi Yamakawa, Kosuke Ushijima, Takuji Fujisawa, Norikazu Kuriya, Hirohisa Kato, Takahiro Inokuchi, Reijiro Mahara, Takao Kurosawa, Masahiko Tohma – 1 October 1994 – Fetal bile acids (1β‐hydroxylated, 6α‐hydroxylated and unsaturated bile acids), especially 1β,3α,7α, 12α‐tetrahydroxy‐5β‐cholan‐24‐oic acid (CA‐1β‐ol), have been detected in urine and feces early in life.

Neville R. Pimstone, Robert C. Stadalnik, David R. Vera, Dusan P. Hutak, Walter L. Trudeau – 1 October 1994 – We have developed a quantitative functional imaging study of the liver using a radiolabeled asialoglycoprotein analog, Tc‐galactosyl‐neoglycoalbumin. Heart and liver time‐activity data can be transformed by automated kinetic analysis into asialoglycoprotein hepatocyte receptor concentration. Twenty‐eight healthy controls, 46 patients with noncholestatic chronic liver injury and 11 patients with primary biliary cirrhosis were studied.

Edward Weir, Qiuyan Chen, Marie C. Defrances, Aaron Bell, Rebecca Taub, Reza Zarnegar – 1 October 1994 – Liver regeneration factor belongs to the leucinezipper family of transcription factors. It was originally cloned and characterized through differential screening of a regenerating rat liver cDNA library. The mRNA for liver regeneration factor‐1 is barely detectable in normal rat liver but is dramatically induced after two‐thirds hepatectomy, with a peak 1 to 3 hr after surgery. The nature of the signaling molecule(s) for this rapid induction is not known.

Hirosumi Oide, Ronald G. Thurman – 1 October 1994 – Ito cells (fat‐storing cells) have been implicated in mechanisms of liver fibrosis, and transforming growth factor‐β1 is a key factor that stimulates collagen production by Ito cells. Moreover, Ito cells are reported to possess contractile proteins and to contract with ligands. We recently reported the presence of L‐type voltage‐operated Ca2+ channels in Kupffer cells. In this study, we examined whether Ito cells contain Ca2+ channels and also evaluated the effect of transforming growth factor‐β1 on Ca2+ channels.

Raymond S. Koff – 1 October 1994

Albert Maroto, Angels Ginès, Joan Saló, Joan Clària, Pere Ginès, Luis Anibarro, Wladimiro Jiménez, Vicente Arroyo, Juan Rodés – 1 October 1994 – Time‐velocity wave‐form analysis of Doppler signals from small intrarenal arteries allows estimation of intrarenal arteriolar vascular resistance. Among the various indexes proposed, the resistive index is the most widely used for this estimation.

Neus Agell, Maria Jesus Pujol, Antonia López‐Girona, Marta Bosch, Jose Luis Rosa, Oriol Bachs – 1 October 1994 – We have investigated the messenger RNAs expressed from the three calmodulin genes during rat liver regeneration. The results revealed that all the calmodulin transcripts increased from 8 hr after a partial hepatectomy, although differences in the timing and the level of expression from the three genes were observed. Calmodulin I transcripts peaked at 16 hr, whereas calmodulin II and calmodulin III progressively increased from 8 to 24 hr.

1 October 1994