Elena Vara, Javier Arias‐Díaz, Juan Torres‐Melero, Cruz García, José M. Rodríguez, José L. Balibrea – 1 October 1994 – Cytokines seem to play an important role in the metabolic disturbances that are commonly associated with sepsis. In this study, we analyzed the effect of tumor necrosis factor, interleukin‐1 and interleukin‐6, as well as that of tumor necrosis factor in combination with interleukin‐1 or interleukin‐6, both on free fatty acids and on phospholipid synthesis by isolated rat hepatocytes.

Yuji Tanaka, Norio Hayashi, Akira Kaneko, Toshifumi Ito, Masayoshi Horimoto, Yutaka Sasaki, Akinori Kasahara, Hideyuki Fusamoto, Takenobu Kamada – 1 October 1994 – To investigate the signaling pathways to Na+/H+ exchanger activation with epidermal growth factor in hepatocytes, we measured changes in cytosolic free calcium and intracellular pH levels at the single‐cell level using digital imaging fluorescence microscopy of fura‐2—or BCECF‐loaded hepatocytes in primary culture.

María Cascales, Alberto Alvarez, Pilar Gascó, Lourdes Fernández‐Simón, Nuria Sanz, Lisardo Boscá – 1 October 1994 – Liver injury was induced by a single dose (60 mg/kg) of cocaine in male albino Swiss mice untreated or pretreated with phenobarbital (in drinking water 1 gm/L), for 5 days before cocaine administration. One parameter of liver injury, serum isocitrate dehydrogenase activity, showed sharp increases at 24 hr of cocaine treatment; we also noted decreased hepatic levels of ATP, GSH, cytochrome P‐450 and NADPH/NADP+ ratio and increases in malondialdehyde concentration.

Raymond S. Koff, Kevin D. Mullen – 1 October 1994

Paolo Angeli, Wladimiro Jiménez, Vicente Arroyo, Harald S. Mackenzie, Ping L. Zhang, Joan Clária, Francisca Rivera, Barry M. Brenner, Joan Rodés – 1 October 1994 – The aim of this study was to assess the effect of HS‐142‐1, a recently discovered specific antagonist of endogenous natriuretic peptides, on systemic hemodynamics, renal function, and the renin‐aldosterone system in rats with cirrhosis and ascites. The study consisted of three protocols, each including 10 conscious control rats and 10 conscious rats with carbontetrachloride‐induced cirrhosis with ascites.

T. Jake Liang, M. Sawkat Anwer, Bruce R. Bacon, Henry C. Bodenheimer, James M. Crawford, Norman D. Grace, Sanjeev Gupta, Joel Lavine, Arun J. Sanyal – 1 October 1994 – One hundred patients underwent transjugular intrahepatic portosystemic shunt (TIPS) creation for variceal bleeding (n = 94), intractable ascites (n = 3), hepatorenal syndrome (n = 2), and preoperative portal decompression (n = 1). Shunts were completed in 96 patients.

Maria Giulia Battelli, Laura Buonamici, Andrea Bolognesi, Fiorenzo Stirpe – 1 October 1994 – A Ber‐H2/saporin immunotoxin, consisting of the single‐chain ribosome‐inactivating protein saporin‐S6 and the anti‐CD30 monoclonal antibody Ber‐H2, gave encouraging results in the treatment of refractory Hodgkin's disease but caused a transient hepatotoxicity. The accumulation of Ber‐H2/saporin conjugate and of its components by rat liver parenchymal and nonparenchymal cells was studied.

Barry J. Potter, Jia‐Zhang Ni, Kathleen Wolfe, Decherd Stump, Paul D. Berk – 1 October 1994 – To determine whether phenobarbital affects hepatocellular bilirubin/sulfobromophthalein uptake mechanism, we administered it to male Sprague‐Dawley rats, body weight 175 ± 25 gm, at doses of 1 to 75 mg/kg body wt/day for 7 days. Control rats were given an equivalent volume of physiological saline solution.

Judy Van De Water, M. Eric Gershwin – 1 October 1994 – Background/Aims: A strong association exists between ulcerative colitis and primary sclerosing cholangitis (PSC). Previously, the presence of a unique epitope shared by colon and biliary epithelial cells was shown by using the novel monoclonal antibody (MAb) 7E12H12 developed against a colonic epithelial protein. In the present study, the presence of circulating autoantibody in PSC against this peptide was examined.

Yoshikazu Murawaki, Yujiro Ikuta, Masahiko Koda, Hironaka Kawasaki – 1 October 1994 – To assess the clinical value of serum biochemical markers, the aminoterminal peptide of type III procollagen, type IV collagen 7S domain, the central triplehelix of type IV collagen and tissue inhibitor of metalloproteinases, as a marker of hepatic fibrosis, we measured these four serum markers in 132 patients with chronic viral liver disease and compared these serum markers with liver histological findings.