Acetylsalicylic acid in the prevention of early stenosis and occlusion of transjugular intrahepatic portal‐systemic stent shunts: A controlled study

Lorenz Theilmann, Peter Sauer, Thomas Roeren, Gerd Otto, Joachim C. Arnold, Gerd Noeldge, Goetz Richter, Adolf Stiehl – 1 September 1994 – Stenosis or occlusion of the transjugular intrahepatic portal‐systemic stent shunt may be initiated by aggregation and activation of thrombocytes on the surface of the metallic stent material. To find effective prevention of this event, we conducted a controlled trial administering acetylsalicylic acid for 3 mo. Forty‐four patients (8 women and 36 men) with portal hypertension were included in this study.

Parenteral calcitonin for metabolic bone disease associated with primary biliary cirrhosis

Andrea Crosignani, Pier Maria Battezzati, Walter Albisetti, Giuseppe Grandinetti, Luca Pietrogrande, Arianna Biffi, Massimo Zuin, Mauro Podda – 1 September 1994 – No satisfactory treatment is available for metabolic bone disease associated with primary biliary cirrhosis. On the basis of the similarities to postmenopausal osteoporosis, the rationale exists for calcitonin to be tested in clinical studies in patients with primary biliary cirrhosis—associated osteoporosis.

Sclerotherapy for male alcoholic cirrhotic patients who have bled from esophageal varices: Results of a randomized, multicenter clinical trial

Pamela Hartigan, The Veterans Affairs Cooperative Variceal Sclerotherapy Group – 1 September 1994 – Sclerotherapy and sham‐sclerotherapy were compared in male alcoholic patients with cirrhosis and bleeding esophageal varices. The prospective, singleblind, randomized clinical trial of 5 yr duration entered 253 male alcoholic patients at 12 Veterans Affairs medical centers. Patients were either actively bleeding from esophageal varices at randomization or they had a history of such bleeding.

Impact of shunt surgery for variceal bleeding in the natural history of ascites in cirrhosis: A retrospective study

Antoni Castells, Joan Saló, Ramon Planas, Juan Carlos Quer, Angels Ginès, Jaume Boix, Pere Ginès, Miquel Angel Gassull, Josep Terés, Vicente Arroyo, Joan Rodés – 1 September 1994 – Despite the efficacy of shunt surgery in the treatment of variceal bleeding, less effective nonoperative therapies are being substituted because surgical shunt does not modify survival and increases hepatic encephalopathy. However, the real impact of shunt surgery on the natural history of ascites and its complications has not been established.

The role of inflammatory mediators on hepatitis B virus surface expression in a transgenic mouse model

1 September 1994 – We have recently reported that administration of recombinant tumor necrosis factor‐alpha to hepatitis B virus transgenic mice reduces the hepatic steadystate content of HBV‐specific mRNA by up to 80% in the absence of liver cell injury. In the current study, we analyzed the regulatory effects of several other inflammatory cytokines in the same transgenic model system. Hepatic HBV mRNA content was reduced by up to 90% following administration of a single noncytopathic dose (100,000U) of interleukin‐2.

Posttranslational events involved in griseofulvin‐induced keratin cytoskeleton alterations

Hermann Salmhofer, Ingrid Rainer, Kurt Zatloukal, Helmut Denk – 1 September 1994 – Alcoholic hepatitis is a disease associated with profound alterations of the hepatocytic intermediate filament cytoskeleton. Similar cytoskeletal alterations can be induced in mice with prolonged feeding of the fungistatic drug griseofulvin. Murine hepatocytic intermediate filaments are composed of equimolar amounts of keratin polypeptides A (type II) and D (type I).

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