Papaverine inhibits bile acid excretion in isolated perfused rat liver

Tomoyuki Kumai, Makoto Hoshino, Tomihiro Hayakawa, Katsuyoshi Higashi – 1 September 1994 – We investigated the effects of papaverine on bile acid excretion into bile in the presence of infusions of taurocholic acid, tauroursodeoxycholic acid, taurochenodeoxycholic acid and taurodehydrocholic acid in a single‐pass, isolated perfused rat liver model.

Immunoglobulins and α1‐acid glycoprotein do not contribute to the cholesterol crystallization—promoting effect of concanavalin a—binding biliary protein

Marianne A. C., De Bruijn, Kam S. Mok, Tiny Out, Guido N. J. Tytgat, Albert K. Groen – 1 September 1994 – Human bile contains cholesterol crystallization—stimulating proteins that can be isolated by concanavalin A—Sepharose chromatography. In the past few years an increasing number of different pronucleating proteins have been identified in the concanavalin A—binding fraction. In this study we attempted to estimate the relative contribution of a number of these proteins to total concanavalin A—binding pronucleating activity.

The eosinophil as an effector cell of the immune response during hepatic allograft rejection

Piet C. De Groen, Gail M. Kephart, Gerald J. Gleich, Jurgen Ludwig – 1 September 1994 – Objective: To evaluate the role of the eosinophil granulocyte during hepatic allograft rejection. Design: (a) A retrospective case‐control study and (b) a prospective study of consecutive liver transplant recipients. Patients: In the retrospective study, eight patients with severe rejection in the first month after liver transplantation were compared with six patients without rejection.

Hepatitis C virus: From epidemiology and molecular virology to immunobiology

Johnson Y. N. Lau – 1 September 1994 – Hepatitis C virus (HCV) is a major cause of posttransfusion and community‐acquired hepatitis, and a majority of individuals infected with this virus will subsequently develop chronic hepatitis. Characterization of the host immune response to this infection is an important first step that should facilitate the development of immunomodulatory agents and vaccines. Cellular immune responses, especially those mediated by cytotoxic T lymphocytes (CTL), are important in the control of many viral diseases.

Changes in distribution and activity of glutamine synthetase in carbon tetrachloride‐induced cirrhosis in the rat: Potential role in hyperammonemia

Rolf Gebhardt, Jürg Reichen – 1 September 1994 – Cirrhosis induced in rats by carbon tetrachloride was used to study alterations in the activities and lobular distribution of carbamoylphosphate synthetase and glutamine synthetase. Specific activity of carbamoylphosphate synthetase in cirrhotic subjects was decreased to 70% of controls. Staining was homogeneous within micronodular areas, but varied from area to area and generally showed a decreased intensity.

A multicenter randomized controlled dose study of ursodeoxycholic acid for chronic hepatitis C

Susumu Takano, Yoshimi Ito, Osamu Yokosuka, Masao Ohto, Katsuo Uchiumi, Katsutaro Hirota, Masao Omata – 1 September 1994 – The effect of ursodeoxycholic acid on liver function tests and on bile acid metabolism was investigated in a multi‐center randomized controlled dose study for chronic hepatitis C. Twenty, 18 and 19 patients were administered 150, 600 and 900 mg/day, respectively of ursodeoxycholic acid every day for 16 wk. Serum liver parameters and bile acid composition in the treatment groups were compared with 17 control patients.

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