Bahri M. Bilir – 1 October 1993 – The developmental regulation of the α‐fetoprotein (AFP) gene in liver results in high‐level expression in the fetus, followed by dramatic transcriptional repression after birth. We have examined the mouse AFP gene for transcriptional control sequences that may be involved in its postnatal repression in liver.
Darius Moradpour, Jack R. Wands, Margherita Melegari – 1 October 1993
Brian J. McMahon – 1 October 1993 – Objective: To assess the long‐term outcome in hepatitis B surface antigen (HBsAg) carriers who have normal liver function tests, focusing on survival and the development of severe liver disease and hepatocellular carcinoma.
1 October 1993
David R. Triger, Fernando Granai, Jocelyn Woodcock, Richard Wise, Bruno P. Imbimbo – 1 October 1993 – The multiple‐dose pharmacokinetics of rufloxacin were investigated in 13 patients with biopsy‐proven cirrhosis and in 5 healthy controls. Rufloxacin was administered once a day for 5 consecutive days, starting with a loading dose of 400 mg on day 1 and 200 mg on the subsequent days. Plasma and urinary drug concentrations were determined by high‐performance liquid chromatography and a microbiological assay.
Renee C. Lin, Feng C. Zhou, Michael J. Fillenwarth, Lawrence Lumeng – 1 October 1993 – Acetaldehyde, a highly reactive intermediate of alcohol metabolism, has been shown to form adducts with liver proteins in rats fed alcohol for long periods. In this report, the zonal distribution of liver proteinacetaldehyde adducts that formed in vivo was studied by means of histoimmunostaining. Rats were pair‐fed alcohol‐containing and alcohol‐free AIN'76 liquid diets for 2 or 11 wk before they were killed and subjected to whole body perfusion with paraformaldehyde.
Renata E. Bluhm, Marshall G. Frazer, Mary Vore, C. Wright Pinson, Kamal F. Badr – 1 October 1993 – Autoradiographic studies have shown that the liver accumulates endothelin. High‐affinity binding sites for endothelin have been identified on rat liver plasma membranes. We investigated the role of endothelin isopeptides as mediators of cholestasis with isolated rat liver perfused by a recirculating solution of buffer and blood.
Z. Reno Vlahcevic, William M. Pandak, Philip B. Hylemon, Douglas M. Heuman – 1 September 1993 – Cholesterol 7αhydroxylase, the rate‐limiting enzyme in the bile acid biosynthetic pathway, is thought to be regulated by hydrophobic bile acids through negative feedback control. The role of cholesterol in the regulation of cholesterol 7αhydroxylase is more controversial, in part because of incomplete understanding of the relationship between the pathways of cholesterol synthesis and degradation.