Carmen Díez‐Fernández, Lisardo Boscá, Lourdes Fernández‐Simón, Alberto Alvarez, María Cascales – 1 October 1993 – Thioacetamide proved to be a potent necrogenic agent when a single dose of 6.6 mmol/kg was administered intraperitoneally to rats. Its necrogenic ability was assessed on the basis of morphological and biochemical changes. The injury of centrilobular hepatocytes showed a peak of cell death 24 hr after thioacetamide administration; it was followed immediately by the regenerative response.

Albert J. Czaja, Herschel A. Carpenter, Paula J. Santrach, S. Breanndan Moore – 1 October 1993 – To assess the frequency and genetic predispositions of concurrent immunological diseases and immunoserological markers in autoimmune hepatitis and chronic viral hepatitis, we assessed 185 patients prospectively, including 122 patients with autoimmune hepatitis and 63 patients with viral disease. Human leukocyte antigens were determined in all patients.

Cornelis H. C. Dejong, Nicolaas E. P. Deutz, Peter B. Soeters – 1 October 1993 – The aim of this study was to evaluate the role of renal ammonia and glutamine metabolism in the metabolic adaptation to chronic liver insufficiency‐induced hyperammonemia in the rat.

Michiaki Hirayama, Yutaka Kohgo, Hitoshi Kondo, Naoaki Shintani, Koshi Fujikawa, Katsunori Sasaki, Junji Kato, Yoshiro Nhtsu – 1 October 1993 – In chronic inflammation it is reported that serum iron is depleted and hepatic iron is increased because of reticuloendothelial system iron blockade.

Simon C. Robson, Delawir Kahn, J. Kruskal, Arthur R. Bird, Ralph E. Kirsch – 1 October 1993 – To assess the contribution of naturally occurring portal‐systemic shunts to the coagulopathy of patients with liver disease, we studied laboratory parameters of hemostasis in 20 adult patients with extrahepatic portal hypertension, secondary to portal vein thrombosis, that had resulted in variceal bleeding. All extrahepatic portal hypertension patients had normal liver function and histological appearance.

Jonathan M. Koff – 1 October 1993

Karin Vanderkerken, Luc Bouwens, Wilfried de Neve, Kit van den Berg, Marijke Baekeland, Nadia Delens, Eddie Wisse – 1 October 1993 – Liver sinusoids contain a population of large granular lymphocytes or natural killer cells, originally termed pit cells. After isolation and purification, these cells were separated into a low‐density and a high‐density fraction. The liver low‐density fraction differs significantly in morphology and function from cells of the blood, whereas the liver high‐density fraction shows intermediate properties.

Fumio Nomura, Masatoshi Noda – 1 October 1993 – ADP ribosylation is considered one of the important covalent modifications of cellular proteins catalyzed by ADP ribosyltransferase, which transfers ADP ribose moiety of NAD to an acceptor protein. Because a growing body of evidence has suggested significant biological roles for mono‐ADP ribosylations in transmembrane signal transduction and other cell metabolism, how alcohol intake alters them is of interest.

Louise Gariépy, Daphna Fenyves, Ibrahim Kassissia, Jean‐Pierre Villeneuve – 1 October 1993 – We studied the steady‐state hepatic extraction and single‐pass hepatic uptake of propranolol in isolated perfused livers from normal rats and compared these values with those of rats with carbon tetrachloride–induced cirrhosis, rats treated with chlorpromazine (an inhibitor of propranolol metabolism) and rats with acute liver injury.

Gregor Zöhrens, Thomas Armbrust, Ursula Pirzer, Karl‐Hermann Meyer zum Büschenfelde, Giuliano Ramadori – 1 October 1993 – To study the influence of chronic hepatitis on intercellular adhesion molecule‐1 serum concentration, we measured intercellular adhesion molecular‐1 in the serum of 84 patients with chronic liver disease (17 chronic persistent hepatitis, 42 chronic active hepatitis and 25 active cirrhosis) caused by hepatitis B virus (n = 46), hepatitis C virus (n = 10) and autoimmunity (n = 28).