Fabio Tarsetti, Renato Lenzi, Roberto Salvi, Ekkehard Schuler, Koshilya Rijhsinghani, Romana Lenzen, Nicola Tavoloni – 1 September 1993 – In an attempt to clarify the role of oval cells in the emergence of hepatocellular carcinoma, we fed rats a choline‐free diet containing 0%, 0.05% or 0.1% ethionine. The incidence and nature of premalignant and malignant hepatic lesions were then related to the degree of oval cell proliferation.

Gabriele Missale, John J. Brems, Howard Takiff, Paul J. Pockros, Francis V. Chisari – 1 September 1993 – The proliferative response of peripheral blood lymphocytes to the HBcAg was compared with serological, molecular and immunohistochemical parameters of hepatitis B virus infection and with biochemical and histological parameters of liver disease in a patient who received a completely human leukocyte antigen class I‐mismatched liver allograft for fulminant hepatitis.

Jorge J. Gumucio, W. Michael McDonnell – 1 September 1993 – Cytotoxic T lymphocytes (CTLs) specific for conserved viral antigens can respond to different strains of virus, in contrast to antibodies, which are generally strain‐specific. The generation of such CTLs in vivo usually requires endogenous expression of the antigen, as occurs in the case of virus infection.

Faye D. Roberts, Paul Charalambous, Linda Fletcher, Lawrie W. Powell, June W. Halliday – 1 September 1993 – The pathogenesis of hepatic fibrosis and cirrhosis in genetic hemochromatosis may involve a direct effect of excess iron on collagen synthesis in the liver. To investigate this theory, we measured procollagen messenger RNA levels (types I, III and IV) in the livers of rats in which we produced chronic parenchymal iron overload by feeding them dietary carbonyl iron (2.5%, wt/wt) for up to 18 mo.

Sebastiaan Esbach, Moniek N. Pieters, Johannes Van Der Boom, Donald Schouten, M. Niels Van Der Heyde, Paul J. M. Roholl, Adriaan Brouwer, Theo J. C. Van Berkel, Dick L. Knook – 1 September 1993 – The interaction of oxidized human low‐density lipoproteins with human and rat liver was analyzed by light and electron microscopy.

1 September 1993

Alfred L. Baker – 1 September 1993 – Essential mixed cryoglobulinemia is frequently associated with chronic hepatitis. This report presents four cases of cryoglobulinemia with vasculitis associated with chronic hepatitis related to hepatitis C virus infection. Hepatitis C virus infection was ascertained in the four patients by both the presence in the serum of anti‐HCV antibodies detected by the fourantigen recombinant immunoblot assay and of HCV RNA detected by polymerase chain reaction.

Robert K. Ockner, Raja M. Kaikaus, Nathan M. Bass – 1 September 1993 – Despite increasing understanding of the genetic control of cell growth and the identification of several involved chemical and infectious factors, the pathogenesis of clinical and experimental hepatocellular carcinoma remains unknown. Available evidence is consistent with the possibility that selected changes in the hepatocellular metabolism of long‐chain fatty acids may contribute significantly to this process.

Kang Jong‐Hon, Yuji Togashi, Hiroshi Kasai, Masuo Hosokawa, Noritoshi Takeichi – 1 September 1993 – Acute hepatitis spontaneously develops in the Long‐Evans Cinnamon rat at the age of 4 mo, and eventually hepatocellular carcinoma develops after the chronic hepatitis that persists for over a year. Previously, abnormal copper accumulation was found in the livers of Long‐Evans Cinnamon rats from birth, and it was reported that short‐term administration of D‐penicillamine, a copper‐chelating agent, prevented acute hepatitis in Long‐Evans Cinnamon rats.

Steven C. Simon – 1 September 1993