Karin Vanderkerken, Luc Bouwens, Wilfried de Neve, Kit van den Berg, Marijke Baekeland, Nadia Delens, Eddie Wisse – 1 October 1993 – Liver sinusoids contain a population of large granular lymphocytes or natural killer cells, originally termed pit cells. After isolation and purification, these cells were separated into a low‐density and a high‐density fraction. The liver low‐density fraction differs significantly in morphology and function from cells of the blood, whereas the liver high‐density fraction shows intermediate properties.

Jonathan M. Koff – 1 October 1993

Simon C. Robson, Delawir Kahn, J. Kruskal, Arthur R. Bird, Ralph E. Kirsch – 1 October 1993 – To assess the contribution of naturally occurring portal‐systemic shunts to the coagulopathy of patients with liver disease, we studied laboratory parameters of hemostasis in 20 adult patients with extrahepatic portal hypertension, secondary to portal vein thrombosis, that had resulted in variceal bleeding. All extrahepatic portal hypertension patients had normal liver function and histological appearance.

Michiaki Hirayama, Yutaka Kohgo, Hitoshi Kondo, Naoaki Shintani, Koshi Fujikawa, Katsunori Sasaki, Junji Kato, Yoshiro Nhtsu – 1 October 1993 – In chronic inflammation it is reported that serum iron is depleted and hepatic iron is increased because of reticuloendothelial system iron blockade.

Cornelis H. C. Dejong, Nicolaas E. P. Deutz, Peter B. Soeters – 1 October 1993 – The aim of this study was to evaluate the role of renal ammonia and glutamine metabolism in the metabolic adaptation to chronic liver insufficiency‐induced hyperammonemia in the rat.

Albert J. Czaja, Herschel A. Carpenter, Paula J. Santrach, S. Breanndan Moore – 1 October 1993 – To assess the frequency and genetic predispositions of concurrent immunological diseases and immunoserological markers in autoimmune hepatitis and chronic viral hepatitis, we assessed 185 patients prospectively, including 122 patients with autoimmune hepatitis and 63 patients with viral disease. Human leukocyte antigens were determined in all patients.

Carmen Díez‐Fernández, Lisardo Boscá, Lourdes Fernández‐Simón, Alberto Alvarez, María Cascales – 1 October 1993 – Thioacetamide proved to be a potent necrogenic agent when a single dose of 6.6 mmol/kg was administered intraperitoneally to rats. Its necrogenic ability was assessed on the basis of morphological and biochemical changes. The injury of centrilobular hepatocytes showed a peak of cell death 24 hr after thioacetamide administration; it was followed immediately by the regenerative response.

Ilene C. Weitz, Howard A. Liebman – 1 October 1993

1 October 1993

Toshiyuki Kitai, Akira Tanaka, Atsuo Tokuka, Koichi Tanaka, Yoshio Yamaoka, Kazue Ozawa, Konomu Hirao – 1 October 1993 – To quantify the changes in oxygen saturation of hemoglobin in the liver in hypoxia and liver transplantation, we applied a novel method using near‐infrared spectroscopy. Instead of the conventional two‐wavelength method, we obtained near‐infrared data from a wide spectral range of 700 nm to 1,000 nm with continuous‐wave spectroscopy.