Renee C. Lin, Feng C. Zhou, Michael J. Fillenwarth, Lawrence Lumeng – 1 October 1993 – Acetaldehyde, a highly reactive intermediate of alcohol metabolism, has been shown to form adducts with liver proteins in rats fed alcohol for long periods. In this report, the zonal distribution of liver proteinacetaldehyde adducts that formed in vivo was studied by means of histoimmunostaining. Rats were pair‐fed alcohol‐containing and alcohol‐free AIN'76 liquid diets for 2 or 11 wk before they were killed and subjected to whole body perfusion with paraformaldehyde.

David R. Triger, Fernando Granai, Jocelyn Woodcock, Richard Wise, Bruno P. Imbimbo – 1 October 1993 – The multiple‐dose pharmacokinetics of rufloxacin were investigated in 13 patients with biopsy‐proven cirrhosis and in 5 healthy controls. Rufloxacin was administered once a day for 5 consecutive days, starting with a loading dose of 400 mg on day 1 and 200 mg on the subsequent days. Plasma and urinary drug concentrations were determined by high‐performance liquid chromatography and a microbiological assay.

1 October 1993

Brian J. McMahon – 1 October 1993 – Objective: To assess the long‐term outcome in hepatitis B surface antigen (HBsAg) carriers who have normal liver function tests, focusing on survival and the development of severe liver disease and hepatocellular carcinoma.

Darius Moradpour, Jack R. Wands, Margherita Melegari – 1 October 1993

Bahri M. Bilir – 1 October 1993 – The developmental regulation of the α‐fetoprotein (AFP) gene in liver results in high‐level expression in the fetus, followed by dramatic transcriptional repression after birth. We have examined the mouse AFP gene for transcriptional control sequences that may be involved in its postnatal repression in liver.

Takeaki Suou, Sadako Yamada, Junko Kobayashi, Ushio Hoshino, Eiji Nishimuki, Hironaka Kawasaki – 1 October 1993 – To evaluate the mechanism of increased serum concentrations of the N‐terminal propeptide of type III procollagen and the 7S fragment of type IV collagen in acute liver injury, we serially measured serum levels of these substances after transcatheter arterial embolization in patients with hepatocellular carcinoma.

Tadashi Terada, Tetsuji Kida, Yasuni Nakanuma – 1 October 1993 – We examined expression of α‐amylase isozymes (pancreatic and salivary), trypsin and pancreatic lipase on the epithelium of extrahepatic peribiliary glands immunohistochemically using 53 autopsied normal extrahepatic bile ducts. Three parts of the extrahepatic bile duct (common bile duct, intrapancreatic bile duct and bile duct at the ampulla of Vater) were examined in each case. Histologically, the extrahepatic bile duct harbored branched tubular glands (extrahepatic peribiliary glands).

James E. Norman, Gilbert W. Beebe, Jay H. Hoofnagle, Leonard B. Seeff – 1 October 1993 – The hypothesis that adult infection with the hepatitis B virus in the United States leads to a carrier state with a high risk of primary liver cancer was tested in two ways: (a) a cohort mortality study of U.S. Army veterans given yellow fever vaccine contaminated with hepatitis B virus in 1942 and controls and (b) a case‐control study comparing veterans with hepatocellular carcinoma in Veterans Affairs hospitals with matched controls with respect to receipt of contaminated vaccine in 1942.

Betty L. Slagle, Yi‐Zhong Zhou, Walter Birchmeier, Kathleen A. Scorsone – 1 October 1993 – Frequent allele loss from chromosome 16q was recently described for human tumors of the breast, prostate gland and liver, indicating the possible presence of a tumor‐suppressor gene on that chromosome arm. In this study, the chromosome 16 allele status of 38 hepatocellular carcinomas in Chinese patients was determined with restriction‐fragmentlength polymorphism analysis.