Bile acids for babies? Diagnosis and treatment of a new category of metabolic liver disease
Frederick J. Suchy – 1 November 1993
Endothelins 1 and 3: Potent cholestatic agents secreted and excreted by the liver that interact with cyclosporine
Renata E. Bluhm, Marshall G. Frazer, Mary Vore, C. Wright Pinson, Kamal F. Badr – 1 October 1993 – Autoradiographic studies have shown that the liver accumulates endothelin. High‐affinity binding sites for endothelin have been identified on rat liver plasma membranes. We investigated the role of endothelin isopeptides as mediators of cholestasis with isolated rat liver perfused by a recirculating solution of buffer and blood.
Zonal distribution of protein‐acetaldehyde adducts in the liver of rats fed alcohol for long periods
Renee C. Lin, Feng C. Zhou, Michael J. Fillenwarth, Lawrence Lumeng – 1 October 1993 – Acetaldehyde, a highly reactive intermediate of alcohol metabolism, has been shown to form adducts with liver proteins in rats fed alcohol for long periods. In this report, the zonal distribution of liver proteinacetaldehyde adducts that formed in vivo was studied by means of histoimmunostaining. Rats were pair‐fed alcohol‐containing and alcohol‐free AIN'76 liquid diets for 2 or 11 wk before they were killed and subjected to whole body perfusion with paraformaldehyde.
Multiple‐dose pharmacokinetics of rufloxacin in patients with cirrhosis
David R. Triger, Fernando Granai, Jocelyn Woodcock, Richard Wise, Bruno P. Imbimbo – 1 October 1993 – The multiple‐dose pharmacokinetics of rufloxacin were investigated in 13 patients with biopsy‐proven cirrhosis and in 5 healthy controls. Rufloxacin was administered once a day for 5 consecutive days, starting with a loading dose of 400 mg on day 1 and 200 mg on the subsequent days. Plasma and urinary drug concentrations were determined by high‐performance liquid chromatography and a microbiological assay.
Notices
1 October 1993
What should we clinicians do for healthy, asymptomatic, hbsag‐positive carriers?
Brian J. McMahon – 1 October 1993 – Objective: To assess the long‐term outcome in hepatitis B surface antigen (HBsAg) carriers who have normal liver function tests, focusing on survival and the development of severe liver disease and hepatocellular carcinoma.
Chasing the escape mutant
Darius Moradpour, Jack R. Wands, Margherita Melegari – 1 October 1993
Lessons from the repression of the α‐fetoprotein gene in the adult liver
Bahri M. Bilir – 1 October 1993 – The developmental regulation of the α‐fetoprotein (AFP) gene in liver results in high‐level expression in the fetus, followed by dramatic transcriptional repression after birth. We have examined the mouse AFP gene for transcriptional control sequences that may be involved in its postnatal repression in liver.