Expression of the terminal protein of hepatitis B virus is associated with failure to respond to interferon therapy

Graham R. Foster, Robert D. Goldin, Andrew Hay, Michael J. McGarvey, George R. Stark, Howard C. Thomas – 1 May 1993 – The terminal protein domain of the hepatitis B viral polymerase can inhibit the cellular response to interferon. To clarify the clinical relevance of this inhibitory effect, we examined the expression of terminal protein in liver biopsy specimens from patients with chronic hepatitis B infection.

A study of oral nutritional support with oxandrolone in malnourished patients with alcoholic hepatitis: Results of a department of veterans affairs cooperative study

Charles L. Mendenhall, Thomas E. Moritz, Gary A. Roselle, Timothy R. Morgan, Bernard A. Nemchausky, Carlo H. Tamburro, Eugene R. Schiff, Craig J. McClain, Luis S. Marsano, John I. Allen, Arun Samanta, Robert E. Weesner, William Henderson, Peter Gartside, Thomas S. Chen, Samuel W. French, Antonio Chedid, Veterans affairs cooperative study group 275 – 1 April 1993 – A Veterans Affairs cooperative study involving 273 male patients was performed to evaluate efficacy of oxandrolone in combination with an enteral food supplement in severe alcoholic hepatitis.

Histological evaluation of the intrahepatic biliary tree in intrahepatic cholesterol stones, including immunohistochemical staining against apolipoprotein A‐1

Tetsuo Ohta, Takukazu Nagakawa, Toshiya Takeda, Luis Fonseca, Masahiro Kanno, Kazuhiro Mori, Masato Kayahara, Keiichi Ueno, Itsuo Miyazaki, Tadashi Terada – 1 April 1993 – Apolipoprotein A‐1 is known to be one of inhibiting factors of cholesterol nucleation in bile, and decreased activity of apolipoprotein A‐1 is considered to predispose cholesterol‐supersaturated bile to formation of cholesterol crystals.

Omeprazole induction of cytochrome P‐450IA2: The importance of selecting the appropriate human model

Paul B. Watkins – 1 April 1993 – Omeprazole has been shown to induce cytochrome P450IA1 and P450IA2 activity in vitro. To reflect cytochrome P450IA2 (CYPIA2) activity in vivo, the 13C‐[N‐3‐methyl]‐caffeine breath test was conducted in 18 volunteers: 12 extensive metabolizers, one intermediate metabolizer, and five poor metabolizers of S‐mephenytoin. Breath tests were performed before treatment with an oral dose of 40 mg omeprazole, on the seventh day of treatment, and after a 7‐day washout period.

Administration of prostaglandin E1 analog reduces rat hepatic and ito cell collagen gene expression and collagen accumulation after bile duct ligation injury

David W. A. Beno, Ronald Espinal, Brian M. Edelstein, Bernard H. Davis – 1 April 1993 – Recent studies suggest that prostaglandin E may have the ability to suppress cytokine responsiveness. We examined the effects of prostaglandin E administration on several parameters of acute and chronic liver injury induced by bile duct ligation. Enisoprost, a prostaglandin E1 analog, was found to suppress early hepatic and Ito cell type I collagen gene expression without‐diminishing the induction of the fibrogenic cytokine transforming growth factor‐β.

Regulation of glycogen phosphorylase activity in isolated human hepatocytes

Stefaan Keppens, Ann Vandekerckhove, Han Moshage, Sing Hiem Yap, Raymond Aerts, Henri de Wulf – 1 April 1993 – Hepatocytes were isolated from human liver tissue by a two‐step perfusion technique. They were treated with vasopressin, angiotensin, ATP and phenylephrine, which are known to be Ca2+‐mediated glycogenolytic agents in rat liver tissue, and as a control, they were treated with the cyclic AMP–mediated hormones glucagon and isoproterenol. All agonists induce a timedependent activation of glycogen phosphorytase.

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